TY - JOUR
T1 - The role of mucins in host-parasite interactions
T2 - Part II - Helminth parasites
AU - Theodoropoulos, Georgios
AU - Hicks, Sally J.
AU - Corfield, Anthony P.
AU - Miller, Bevis G.
AU - Carrington, Steve D.
PY - 2001
Y1 - 2001
N2 - Some parasites express mucin-like molecules. These have possible roles in attachment and invasion of host cells and in the avoidance of host immune processes. Enzymes of parasite origin might also facilitate infection, either by degrading host mucus barriers or by generating binding sites on host cells. Host mucins have roles in preventing parasite establishment or in parasite expulsion. They, in turn, might be exploited by parasites, either as sources of fuel or binding sites, or as host-finding targets. Here, we describe the biochemical properties of mucins and mucin-like molecules in relation to interactions (established and putative) between helminth parasites and their hosts.
AB - Some parasites express mucin-like molecules. These have possible roles in attachment and invasion of host cells and in the avoidance of host immune processes. Enzymes of parasite origin might also facilitate infection, either by degrading host mucus barriers or by generating binding sites on host cells. Host mucins have roles in preventing parasite establishment or in parasite expulsion. They, in turn, might be exploited by parasites, either as sources of fuel or binding sites, or as host-finding targets. Here, we describe the biochemical properties of mucins and mucin-like molecules in relation to interactions (established and putative) between helminth parasites and their hosts.
UR - http://www.scopus.com/inward/record.url?scp=0035005950&partnerID=8YFLogxK
U2 - 10.1016/S1471-4922(00)01775-X
DO - 10.1016/S1471-4922(00)01775-X
M3 - Article
C2 - 11286796
AN - SCOPUS:0035005950
SN - 1471-4922
VL - 17
SP - 130
EP - 135
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 3
ER -
