TY - JOUR
T1 - The influence of the Pro12Ala mutation of the PPAR-gamma receptor gene on metabolic and clinical characteristics in treatment-naäve patients with type 2 diabetes
AU - Ahluwalia, M.
AU - Evans, M.
AU - Morris, K.
AU - Currie, C.
AU - Davies, S.
AU - Rees, A.
AU - Thomas, A.
PY - 2002/11
Y1 - 2002/11
N2 - Peroxisome proliferator activated receptor-gamma is an important factor in adipocyte differentiation and energy metabolism and is thus a candidate gene for obesity, insulin resistance and dyslipidaemia. We therefore assessed the associations between the most common variant of the PPAR-γ, the Pro12Ala (P12A) substitution in the PPAR-γ2. gene, with BMI, blood pressure, fasting plasma glucose, HbA1c, total cholesterol, LDL and HDL cholesterol and plasma triglyceride in 183 treatment-naïve patients with type 2 diabetes (T2D). The P12A allele associated with lower fasting plasma glucose but had no influence on HbA1c, or BMI. In obese patients (BMI > 29 kg/m2), the P12A substitution associated with elevated total and non-HDL cholesterol levels.
AB - Peroxisome proliferator activated receptor-gamma is an important factor in adipocyte differentiation and energy metabolism and is thus a candidate gene for obesity, insulin resistance and dyslipidaemia. We therefore assessed the associations between the most common variant of the PPAR-γ, the Pro12Ala (P12A) substitution in the PPAR-γ2. gene, with BMI, blood pressure, fasting plasma glucose, HbA1c, total cholesterol, LDL and HDL cholesterol and plasma triglyceride in 183 treatment-naïve patients with type 2 diabetes (T2D). The P12A allele associated with lower fasting plasma glucose but had no influence on HbA1c, or BMI. In obese patients (BMI > 29 kg/m2), the P12A substitution associated with elevated total and non-HDL cholesterol levels.
KW - Cholesterol
KW - Glucose
KW - PPAR-γ
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=0036847519&partnerID=8YFLogxK
U2 - 10.1046/j.1463-1326.2002.00230.x
DO - 10.1046/j.1463-1326.2002.00230.x
M3 - Article
C2 - 12406034
AN - SCOPUS:0036847519
SN - 1462-8902
VL - 4
SP - 376
EP - 378
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
IS - 6
ER -
