TY - JOUR
T1 - The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs
AU - Lin, Huan
AU - Li, Xuanyi
AU - Zhang, Huiying
AU - Mu, Yi
AU - Wang, Xi
AU - Konduru, Naveena
AU - Ji, Renlong
AU - Liu, Wen
AU - Fei, Zhao
AU - Jiang, Wen
AU - Qiao, Yuehua
N1 - Copyright © 2025 Lin, Li, Zhang, Mu, Wang, Konduru, Ji, Liu, Fei, Jiang and Qiao.
PY - 2025/1/23
Y1 - 2025/1/23
N2 - Background: Inner ear disorders, such as EH, commonly lead to hearing loss and vestibular dysfunction. EH is particularly prevalent in various inner ear diseases, including Meniere’s disease. We aimed to evaluate the effects of EH on WAI and OAEs. Objective: This study explores the potential of wideband acoustic immittance (WAI) and otoacoustic emissions (OAEs) for the early detection of changes in acoustic transmission associated with vasopressin-induced endolymphatic hydrops (EH) in a guinea pig model. Methods: We induced EH in guinea pigs via daily intraperitoneal injections of arginine vasopressin over 14 consecutive days. Auditory function was assessed using Auditory Brainstem Responses (ABR), while changes in sound energy transmission were measured using WAI and Distortion Products Otoacoustic Emissions (DPOAE). Results: Increased ABR thresholds in EH models were statistically significant (p < 0.05). After 14 days of EH induction, absorbance at 1 kHz significantly increased, whereas it significantly decreased at 4 kHz and 6 kHz (p < 0.05). DPOAE measures, both magnitude and phase, showed no significant changes (p > 0.05). Conclusion: WAI demonstrates greater sensitivity than DPOAE in the early detection of acoustic transmission alterations in EH models, suggesting its utility as a diagnostic tool in early-stage inner ear disorders.
AB - Background: Inner ear disorders, such as EH, commonly lead to hearing loss and vestibular dysfunction. EH is particularly prevalent in various inner ear diseases, including Meniere’s disease. We aimed to evaluate the effects of EH on WAI and OAEs. Objective: This study explores the potential of wideband acoustic immittance (WAI) and otoacoustic emissions (OAEs) for the early detection of changes in acoustic transmission associated with vasopressin-induced endolymphatic hydrops (EH) in a guinea pig model. Methods: We induced EH in guinea pigs via daily intraperitoneal injections of arginine vasopressin over 14 consecutive days. Auditory function was assessed using Auditory Brainstem Responses (ABR), while changes in sound energy transmission were measured using WAI and Distortion Products Otoacoustic Emissions (DPOAE). Results: Increased ABR thresholds in EH models were statistically significant (p < 0.05). After 14 days of EH induction, absorbance at 1 kHz significantly increased, whereas it significantly decreased at 4 kHz and 6 kHz (p < 0.05). DPOAE measures, both magnitude and phase, showed no significant changes (p > 0.05). Conclusion: WAI demonstrates greater sensitivity than DPOAE in the early detection of acoustic transmission alterations in EH models, suggesting its utility as a diagnostic tool in early-stage inner ear disorders.
KW - DPOAE
KW - guinea pigs
KW - endolymphatic hydrops
KW - ABR
KW - wideband acoustic immittance
UR - http://www.scopus.com/inward/record.url?scp=85216962493&partnerID=8YFLogxK
U2 - 10.3389/fneur.2025.1444928
DO - 10.3389/fneur.2025.1444928
M3 - Article
C2 - 39916945
SN - 1664-2295
VL - 16
SP - 1444928
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 1444928
ER -