The effect of dietary antioxidants on levels of DNA damage in humans: a systematic review

Sophie Davies; Y.S.  Lee; R.M. Elliot

doi:10.1111/jhn.12535

The effect of dietary antioxidants on levels of DNA damage in humans: a systematic review

Sophie Davies, Y.S. Lee, R.M. Elliot

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Oxidative stress is caused by an excess of reactive oxygen species (ROS) is associated with numerous chronic diseases, such as cardiovascular disease and cancer. The antioxidant hypothesis suggests that dietary antioxidants help protect tissue integrity by reducing cellular damage, including damage to DNA caused by ROS. Although protective findings are apparent in epidemiological studies which associate an increased amount of antioxidant-rich fruit and vegetables intake with a lower incidence of mortality, the strength of evidence from intervention studies is weak and inconsistent. The aim of the study was to analyse the effect of antioxidant supplementation on levels of DNA damage by conducting a systematic review of human randomised controlled trials (RCT).

Original language	English
Pages (from-to)	20-21
Number of pages	1
Journal	Journal of Human Nutrition and Dietetics
Volume	31
Issue number	S1
DOIs	https://doi.org/10.1111/jhn.12535
Publication status	Published - 1 Mar 2018
Externally published	Yes
Event	British Dietetic Association Research Symposium 2017 - Birmingham, United Kingdom Duration: 6 Dec 2017 → 6 Dec 2017

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/jhn.12535Licence: Free Access/Under Copyright

Cite this

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title = "The effect of dietary antioxidants on levels of DNA damage in humans: a systematic review",

abstract = "Oxidative stress is caused by an excess of reactive oxygen species (ROS) is associated with numerous chronic diseases, such as cardiovascular disease and cancer. The antioxidant hypothesis suggests that dietary antioxidants help protect tissue integrity by reducing cellular damage, including damage to DNA caused by ROS. Although protective findings are apparent in epidemiological studies which associate an increased amount of antioxidant-rich fruit and vegetables intake with a lower incidence of mortality, the strength of evidence from intervention studies is weak and inconsistent. The aim of the study was to analyse the effect of antioxidant supplementation on levels of DNA damage by conducting a systematic review of human randomised controlled trials (RCT).",

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AU - Lee, Y.S.

AU - Elliot, R.M.

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N2 - Oxidative stress is caused by an excess of reactive oxygen species (ROS) is associated with numerous chronic diseases, such as cardiovascular disease and cancer. The antioxidant hypothesis suggests that dietary antioxidants help protect tissue integrity by reducing cellular damage, including damage to DNA caused by ROS. Although protective findings are apparent in epidemiological studies which associate an increased amount of antioxidant-rich fruit and vegetables intake with a lower incidence of mortality, the strength of evidence from intervention studies is weak and inconsistent. The aim of the study was to analyse the effect of antioxidant supplementation on levels of DNA damage by conducting a systematic review of human randomised controlled trials (RCT).

AB - Oxidative stress is caused by an excess of reactive oxygen species (ROS) is associated with numerous chronic diseases, such as cardiovascular disease and cancer. The antioxidant hypothesis suggests that dietary antioxidants help protect tissue integrity by reducing cellular damage, including damage to DNA caused by ROS. Although protective findings are apparent in epidemiological studies which associate an increased amount of antioxidant-rich fruit and vegetables intake with a lower incidence of mortality, the strength of evidence from intervention studies is weak and inconsistent. The aim of the study was to analyse the effect of antioxidant supplementation on levels of DNA damage by conducting a systematic review of human randomised controlled trials (RCT).

U2 - 10.1111/jhn.12535

DO - 10.1111/jhn.12535

M3 - Meeting Abstract

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