TY - JOUR
T1 - The Dynamic Relationship between the Glymphatic System, Aging, Memory, and Sleep
AU - Voumvourakis, Konstantinos I.
AU - Sideri, Eleni
AU - Papadimitropoulos, Georgios N.
AU - Tsantzali, Ioanna
AU - Hewlett, Paul
AU - Kitsos, Dimitrios
AU - Stefanou, Marianna
AU - Bonakis, Anastasios
AU - Giannopoulos, Sotirios
AU - Tsivgoulis, Georgios
AU - Paraskevas, George P.
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/7/25
Y1 - 2023/7/25
N2 - The process of memory entails the activation of numerous neural networks and biochemical pathways throughout the brain. The phenomenon of memory decline in relation to aging has been the subject of extensive research for several decades. The correlation between the process of aging and memory is intricate and has various aspects to consider. Throughout the aging process, there are various alterations that take place within the brain and, as expected, affect other functions that have already been linked to memory and its function such as involving microcirculation and sleep. Recent studies provide an understanding of how these mechanisms may be interconnected through the relatively new concept of the glymphatic system. The glymphatic system is strongly correlated to sleep processes. Sleep helps the glymphatic system remove brain waste solutes. Astrocytes expand and contract to form channels for cerebrospinal fluid (CSF) to wash through the brain and eliminate waste. However, the details have not been totally elusive, but the discovery of what we call the glymphatic system enables us to connect many pieces of physiology to understand how such factors are interconnected and the interplay between them. Thus, the purpose of this review is to discuss how the glymphatic system, sleep, memory, and aging are interconnected through a network of complex mechanisms and dynamic interactions.
AB - The process of memory entails the activation of numerous neural networks and biochemical pathways throughout the brain. The phenomenon of memory decline in relation to aging has been the subject of extensive research for several decades. The correlation between the process of aging and memory is intricate and has various aspects to consider. Throughout the aging process, there are various alterations that take place within the brain and, as expected, affect other functions that have already been linked to memory and its function such as involving microcirculation and sleep. Recent studies provide an understanding of how these mechanisms may be interconnected through the relatively new concept of the glymphatic system. The glymphatic system is strongly correlated to sleep processes. Sleep helps the glymphatic system remove brain waste solutes. Astrocytes expand and contract to form channels for cerebrospinal fluid (CSF) to wash through the brain and eliminate waste. However, the details have not been totally elusive, but the discovery of what we call the glymphatic system enables us to connect many pieces of physiology to understand how such factors are interconnected and the interplay between them. Thus, the purpose of this review is to discuss how the glymphatic system, sleep, memory, and aging are interconnected through a network of complex mechanisms and dynamic interactions.
KW - aging
KW - glymphatic system
KW - memory
KW - molecular system
KW - neuroinflammation
UR - http://www.scopus.com/inward/record.url?scp=85168913770&partnerID=8YFLogxK
U2 - 10.3390/biomedicines11082092
DO - 10.3390/biomedicines11082092
M3 - Review article
AN - SCOPUS:85168913770
SN - 2227-9059
VL - 11
JO - Biomedicines
JF - Biomedicines
IS - 8
M1 - 2092
ER -