Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins

Sarah E. Maddocks*, Petra C.F. Oyston

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

680 Citations (Scopus)

Abstract

The LysR family of transcriptional regulators represents the most abundant type of transcriptional regulator in the prokaryotic kingdom. Members of this family have a conserved structure with an N-terminal DNA-binding helix-turn-helix motif and a C-terminal co-inducer-binding domain. Despite considerable conservation both structurally and functionally, LysR-type transcriptional regulators (LTTRs) regulate a diverse set of genes, including those involved in virulence, metabolism, quorum sensing and motility. Numerous structural and transcriptional studies of members of the LTTR family are helping to unravel a compelling paradigm that has evolved from the original observations and conclusions that were made about this family of transcriptional regulators.

Original languageEnglish
Pages (from-to)3609-3623
Number of pages15
JournalMicrobiology (United Kingdom)
Volume154
Issue number12
DOIs
Publication statusPublished - 1 Dec 2008
Externally publishedYes

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