Role of adipocyte-derived extracellular vesicles in vascular inflammation

Katherine D. Connolly; D. Aled Rees; Philip E. James

doi:10.1016/j.freeradbiomed.2021.04.031

Role of adipocyte-derived extracellular vesicles in vascular inflammation

Katherine D. Connolly, D. Aled Rees, Philip E. James^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

4 Downloads (Pure)

Abstract

Extracellular vesicles (EVs) are nanometre-sized vesicles released from most cells, including adipocytes. Relatively little is known about adipocyte-derived EVs (ADEVs) in comparison to other EV subtypes, though interest in ADEVs as potential paracrine and endocrine communicators of adipose tissue in obesity is building. Current evidence indicates that ADEVs contribute to the development of adipose tissue dysfunction; a key feature of obese adipose tissue that it is associated with obesity-related comorbidities including cardiovascular disease (CVD). This review summarises our current knowledge of ADEVs in the development of adipose tissue dysfunction and the potential of ADEVs to disrupt redox signalling and exert vascular effects that may exacerbate CVD in obesity.

Original language	English
Pages (from-to)	58-64
Number of pages	7
Journal	Free Radical Biology and Medicine
Volume	172
DOIs	https://doi.org/10.1016/j.freeradbiomed.2021.04.031
Publication status	Published - 4 Jun 2021

Keywords

Adipocyte dysfunction
Adipocytes
Adipose tissue
Extracellular vesicles
Obesity
Vascular inflammation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.freeradbiomed.2021.04.031

FRBM Connolly et al_revised manuscriptAccepted author manuscript, 311 KBLicence: CC BY-NC-ND

Cite this

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title = "Role of adipocyte-derived extracellular vesicles in vascular inflammation",

abstract = "Extracellular vesicles (EVs) are nanometre-sized vesicles released from most cells, including adipocytes. Relatively little is known about adipocyte-derived EVs (ADEVs) in comparison to other EV subtypes, though interest in ADEVs as potential paracrine and endocrine communicators of adipose tissue in obesity is building. Current evidence indicates that ADEVs contribute to the development of adipose tissue dysfunction; a key feature of obese adipose tissue that it is associated with obesity-related comorbidities including cardiovascular disease (CVD). This review summarises our current knowledge of ADEVs in the development of adipose tissue dysfunction and the potential of ADEVs to disrupt redox signalling and exert vascular effects that may exacerbate CVD in obesity.",

keywords = "Adipocyte dysfunction, Adipocytes, Adipose tissue, Extracellular vesicles, Obesity, Vascular inflammation",

author = "Connolly, {Katherine D.} and Rees, {D. Aled} and James, {Philip E.}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = jun,

day = "4",

doi = "10.1016/j.freeradbiomed.2021.04.031",

language = "English",

volume = "172",

pages = "58--64",

journal = "Free Radical Biology and Medicine",

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TY - JOUR

T1 - Role of adipocyte-derived extracellular vesicles in vascular inflammation

AU - Connolly, Katherine D.

AU - Rees, D. Aled

AU - James, Philip E.

PY - 2021/6/4

Y1 - 2021/6/4

N2 - Extracellular vesicles (EVs) are nanometre-sized vesicles released from most cells, including adipocytes. Relatively little is known about adipocyte-derived EVs (ADEVs) in comparison to other EV subtypes, though interest in ADEVs as potential paracrine and endocrine communicators of adipose tissue in obesity is building. Current evidence indicates that ADEVs contribute to the development of adipose tissue dysfunction; a key feature of obese adipose tissue that it is associated with obesity-related comorbidities including cardiovascular disease (CVD). This review summarises our current knowledge of ADEVs in the development of adipose tissue dysfunction and the potential of ADEVs to disrupt redox signalling and exert vascular effects that may exacerbate CVD in obesity.

AB - Extracellular vesicles (EVs) are nanometre-sized vesicles released from most cells, including adipocytes. Relatively little is known about adipocyte-derived EVs (ADEVs) in comparison to other EV subtypes, though interest in ADEVs as potential paracrine and endocrine communicators of adipose tissue in obesity is building. Current evidence indicates that ADEVs contribute to the development of adipose tissue dysfunction; a key feature of obese adipose tissue that it is associated with obesity-related comorbidities including cardiovascular disease (CVD). This review summarises our current knowledge of ADEVs in the development of adipose tissue dysfunction and the potential of ADEVs to disrupt redox signalling and exert vascular effects that may exacerbate CVD in obesity.

KW - Adipocyte dysfunction

KW - Adipocytes

KW - Adipose tissue

KW - Extracellular vesicles

KW - Obesity

KW - Vascular inflammation

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U2 - 10.1016/j.freeradbiomed.2021.04.031

DO - 10.1016/j.freeradbiomed.2021.04.031

M3 - Review article

C2 - 34052345

AN - SCOPUS:85108176359

SN - 0891-5849

VL - 172

SP - 58

EP - 64

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

ER -

Role of adipocyte-derived extracellular vesicles in vascular inflammation

Abstract

Keywords

UN SDGs

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