Pulmonary mechanics and gas exchange during exercise in Kenyan distance runners

Glen E. Foster, Michael S. Koehle, Paolo B. Dominelli, Francis M. Mwangi, Vincent O. Onywera, Michael K. Boit, Joshua C. Tremblay, Chepleting Boit, A. William Sheel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to determine arterial blood gases, the mechanical limits for generating expiratory flow and the work performed by the respiratory muscles during treadmill exercise in Kenyan runners. Methods: Kenyan runners (10 men and 4 women; mean ± SD age = 25.2 ± 1.3 yr) were instrumented with a radial artery catheter, an esophageal balloon-tipped catheter, and an esophageal temperature probe for the determination of blood gases, the work of breathing and core temperature, respectively. Testing occurred at 1545 m above sea level. Results: There were significant decreases in the arterial partial pressure of O2 and oxyhemoglobin saturation and a widening of the alveolar-to-arterial difference in O2 from rest to peak exercise. The mechanical work of breathing increased with increasing minute ventilation and was commensurate with values expected for treadmill running in elite athletes. During heavy exercise, significant expiratory flow limitation was present in half of the subjects while the remaining subjects demonstrated impending flow limitation. Conclusions: Pulmonary system limitations were present in Kenyan runners in the form of exercise-induced arterial hypoxemia, expiratory flow limitation, and high levels of respiratory muscle work. It appears that Kenyan runners do not posses a pulmonary system that confers a physiological advantage.

Original languageEnglish
Pages (from-to)702-710
Number of pages9
JournalMedicine and Science in Sports and Exercise
Volume46
Issue number4
DOIs
Publication statusPublished - Apr 2014
Externally publishedYes

Keywords

  • Exercise hyperpnea
  • expiratory flow limitation
  • hypoxemia
  • work of breathing

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