Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression

Claire M. Kelly; Sophie V. Precious; Caroline Scherf; Richard Penketh; Nazar N. Amso; Alysia Battersby; Nicholas D. Allen; Stephen B. Dunnett; Anne E. Rosser

doi:10.1038/nmeth.1308

Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression

Claire M. Kelly^*, Sophie V. Precious, Caroline Scherf, Richard Penketh, Nazar N. Amso, Alysia Battersby, Nicholas D. Allen, Stephen B. Dunnett, Anne E. Rosser

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell-derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.

Original language	English
Pages (from-to)	271-273
Number of pages	3
Journal	Nature Methods
Volume	6
Issue number	4
DOIs	https://doi.org/10.1038/nmeth.1308
Publication status	Published - 8 Mar 2009
Externally published	Yes

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10.1038/nmeth.1308

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abstract = "Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell-derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.",

author = "Kelly, {Claire M.} and Precious, {Sophie V.} and Caroline Scherf and Richard Penketh and Amso, {Nazar N.} and Alysia Battersby and Allen, {Nicholas D.} and Dunnett, {Stephen B.} and Rosser, {Anne E.}",

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AU - Kelly, Claire M.

AU - Precious, Sophie V.

AU - Scherf, Caroline

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AU - Amso, Nazar N.

AU - Battersby, Alysia

AU - Allen, Nicholas D.

AU - Dunnett, Stephen B.

AU - Rosser, Anne E.

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Y1 - 2009/3/8

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AB - Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell-derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.

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Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression

Abstract

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