Abstract
Everyday complex and stressful real-life situations can overwhelm the human brain to an extent that the person is no longer able to accurately evaluate the situation and persists in irrational actions or strategies. Safety analyses reveal that such perseverative behavior is exhibited by operators in many critical domains, which can lead to potentially fatal incidents. There are neuroimaging evidences of changes in healthy brain functioning when engaged in non-adaptive behaviors that are akin to executive deficits such as perseveration shown in patients with brain lesion. In this respect, we suggest a cognitive continuum whereby stressors can render the healthy brain temporarily impaired. We show that the dorsolateral prefrontal cortex is a key structure for executive and attentional control whereby any transient (stressors, neurostimulation) or permanent (lesion) impairment compromises adaptive behavior. Using this neuropsychological insight, we discuss solutions involving training, neurostimulation, and the design of cognitive countermeasures for mitigating perseveration.
| Original language | English |
|---|---|
| Pages (from-to) | 252-262 |
| Number of pages | 11 |
| Journal | Neuroscience and Biobehavioral Reviews |
| Volume | 100 |
| Early online date | 14 Mar 2019 |
| DOIs | |
| Publication status | Published - 21 Mar 2019 |
Keywords
- Attentional control
- Cognitive countermeasures
- DLPFC impairment
- Executive control
- Human error
- Perseveration
