Molecular scanning of candidate mitochondrial tRNA genes in type 2 (non-insulin dependent) diabetes mellitus

A. W. Thomas; A. Edwards; E. J. Sherratt; A. Majid; J. Gagg; J. C. Alcolado

doi:10.1136/jmg.33.3.253

Molecular scanning of candidate mitochondrial tRNA genes in type 2 (non-insulin dependent) diabetes mellitus

A. W. Thomas, A. Edwards, E. J. Sherratt, A. Majid, J. Gagg, J. C. Alcolado^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Mitochondrial DNA (mtDNA) gene defects may play a role in the development of non-insulin dependent diabetes mellitus (NIDDM). In order to search for potentially diabetogenic mtDNA defects we have applied the technique of single stranded conformational polymorphism (SSCP) analysis to 124 patients with a history of NIDDM and 40 non-diabetic controls. No new heteroplasmic mutations were detected. However, a variety of homoplasmic variants were found in patients with NIDDM; some of these merit further investigation.

Original language	English
Pages (from-to)	253-255
Number of pages	3
Journal	Journal of Medical Genetics
Volume	33
Issue number	3
DOIs	https://doi.org/10.1136/jmg.33.3.253
Publication status	Published - Mar 1996
Externally published	Yes

Keywords

Diabetes
MELAS
Mitochondrial DNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/jmg.33.3.253

Cite this

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abstract = "Mitochondrial DNA (mtDNA) gene defects may play a role in the development of non-insulin dependent diabetes mellitus (NIDDM). In order to search for potentially diabetogenic mtDNA defects we have applied the technique of single stranded conformational polymorphism (SSCP) analysis to 124 patients with a history of NIDDM and 40 non-diabetic controls. No new heteroplasmic mutations were detected. However, a variety of homoplasmic variants were found in patients with NIDDM; some of these merit further investigation.",

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AU - Thomas, A. W.

AU - Edwards, A.

AU - Sherratt, E. J.

AU - Majid, A.

AU - Gagg, J.

AU - Alcolado, J. C.

PY - 1996/3

Y1 - 1996/3

N2 - Mitochondrial DNA (mtDNA) gene defects may play a role in the development of non-insulin dependent diabetes mellitus (NIDDM). In order to search for potentially diabetogenic mtDNA defects we have applied the technique of single stranded conformational polymorphism (SSCP) analysis to 124 patients with a history of NIDDM and 40 non-diabetic controls. No new heteroplasmic mutations were detected. However, a variety of homoplasmic variants were found in patients with NIDDM; some of these merit further investigation.

AB - Mitochondrial DNA (mtDNA) gene defects may play a role in the development of non-insulin dependent diabetes mellitus (NIDDM). In order to search for potentially diabetogenic mtDNA defects we have applied the technique of single stranded conformational polymorphism (SSCP) analysis to 124 patients with a history of NIDDM and 40 non-diabetic controls. No new heteroplasmic mutations were detected. However, a variety of homoplasmic variants were found in patients with NIDDM; some of these merit further investigation.

KW - Diabetes

KW - MELAS

KW - Mitochondrial DNA

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SP - 253

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JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

IS - 3

ER -

Molecular scanning of candidate mitochondrial tRNA genes in type 2 (non-insulin dependent) diabetes mellitus

Abstract

Keywords

UN SDGs

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