Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG

Yuexin Cai; Jiahong Li; Yanhong Chen; Wan Chen; Caiping Dang; Fei Zhao; Wenrui Li; Guisheng Chen; Suijun Chen; Maojin Liang; Yiqing Zheng

doi:10.3389/fnins.2019.00851

Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG

Yuexin Cai, Jiahong Li, Yanhong Chen, Wan Chen, Caiping Dang, Fei Zhao, Wenrui Li, Guisheng Chen, Suijun Chen, Maojin Liang, Yiqing Zheng^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

This study aimed to identify the mechanism behind idiopathic sudden sensorineural hearing loss (ISSNHL) in patients with tinnitus by investigating aberrant activity in areas of the brain and functional connectivity. High-density electroencephalography (EEG) was used to investigate central nervous changes in 25 ISSNHL subjects and 27 healthy controls. ISSNHL subjects had significantly reduced activity in the left frontal lobe at the alpha 2 frequency band compared with controls. Linear lagged connectivity and lagged coherence analysis showed significantly reduced functional connectivity between the temporal gyrus and supramarginal gyrus at the gamma 2 frequency band in the ISSNHL group. Additionally, a significantly reduced functional connectivity was found between the central cingulate gyrus and frontal lobe under lagged phase synchronization analysis. These results strongly indicate inhibition of brain area activity and change in functional connectivity in ISSNHL with tinnitus patients.

Original language	English
Article number	851
Journal	Frontiers in Neuroscience
Volume	13
DOIs	https://doi.org/10.3389/fnins.2019.00851
Publication status	Published - 14 Aug 2019

Keywords

EEG
ISSNHL
functional connectivity
source localization
tinnitus

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10.3389/fnins.2019.00851

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title = "Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG",

abstract = "This study aimed to identify the mechanism behind idiopathic sudden sensorineural hearing loss (ISSNHL) in patients with tinnitus by investigating aberrant activity in areas of the brain and functional connectivity. High-density electroencephalography (EEG) was used to investigate central nervous changes in 25 ISSNHL subjects and 27 healthy controls. ISSNHL subjects had significantly reduced activity in the left frontal lobe at the alpha 2 frequency band compared with controls. Linear lagged connectivity and lagged coherence analysis showed significantly reduced functional connectivity between the temporal gyrus and supramarginal gyrus at the gamma 2 frequency band in the ISSNHL group. Additionally, a significantly reduced functional connectivity was found between the central cingulate gyrus and frontal lobe under lagged phase synchronization analysis. These results strongly indicate inhibition of brain area activity and change in functional connectivity in ISSNHL with tinnitus patients.",

keywords = "EEG, ISSNHL, functional connectivity, source localization, tinnitus",

author = "Yuexin Cai and Jiahong Li and Yanhong Chen and Wan Chen and Caiping Dang and Fei Zhao and Wenrui Li and Guisheng Chen and Suijun Chen and Maojin Liang and Yiqing Zheng",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2019 Cai, Li, Chen, Chen, Dang, Zhao, Li, Chen, Chen, Liang and Zheng.",

year = "2019",

month = aug,

day = "14",

doi = "10.3389/fnins.2019.00851",

language = "English",

volume = "13",

journal = "Frontiers in Neuroscience",

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AU - Cai, Yuexin

AU - Li, Jiahong

AU - Chen, Yanhong

AU - Chen, Wan

AU - Dang, Caiping

AU - Zhao, Fei

AU - Li, Wenrui

AU - Chen, Guisheng

AU - Chen, Suijun

AU - Liang, Maojin

AU - Zheng, Yiqing

PY - 2019/8/14

Y1 - 2019/8/14

N2 - This study aimed to identify the mechanism behind idiopathic sudden sensorineural hearing loss (ISSNHL) in patients with tinnitus by investigating aberrant activity in areas of the brain and functional connectivity. High-density electroencephalography (EEG) was used to investigate central nervous changes in 25 ISSNHL subjects and 27 healthy controls. ISSNHL subjects had significantly reduced activity in the left frontal lobe at the alpha 2 frequency band compared with controls. Linear lagged connectivity and lagged coherence analysis showed significantly reduced functional connectivity between the temporal gyrus and supramarginal gyrus at the gamma 2 frequency band in the ISSNHL group. Additionally, a significantly reduced functional connectivity was found between the central cingulate gyrus and frontal lobe under lagged phase synchronization analysis. These results strongly indicate inhibition of brain area activity and change in functional connectivity in ISSNHL with tinnitus patients.

AB - This study aimed to identify the mechanism behind idiopathic sudden sensorineural hearing loss (ISSNHL) in patients with tinnitus by investigating aberrant activity in areas of the brain and functional connectivity. High-density electroencephalography (EEG) was used to investigate central nervous changes in 25 ISSNHL subjects and 27 healthy controls. ISSNHL subjects had significantly reduced activity in the left frontal lobe at the alpha 2 frequency band compared with controls. Linear lagged connectivity and lagged coherence analysis showed significantly reduced functional connectivity between the temporal gyrus and supramarginal gyrus at the gamma 2 frequency band in the ISSNHL group. Additionally, a significantly reduced functional connectivity was found between the central cingulate gyrus and frontal lobe under lagged phase synchronization analysis. These results strongly indicate inhibition of brain area activity and change in functional connectivity in ISSNHL with tinnitus patients.

KW - EEG

KW - ISSNHL

KW - functional connectivity

KW - source localization

KW - tinnitus

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DO - 10.3389/fnins.2019.00851

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SN - 1662-4548

VL - 13

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

M1 - 851

ER -

Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG

Abstract

Keywords

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