Fractal analysis of viscoelastic data with automated gel point location and its potential application in the investigation of therapeutically modified blood coagulation

P. Adrian Evans; Matthew Lawrence; R. H.Keith Morris; Naresh Thirumalai; Roger Munro; Lisa Wakeman; Andrew Beddel; P. Rhodri Williams; Matthew Barrow; Daniel Curtis; M. Rowan Brown; Karl Hawkins

doi:10.1007/s00397-010-0472-7

Fractal analysis of viscoelastic data with automated gel point location and its potential application in the investigation of therapeutically modified blood coagulation

P. Adrian Evans, Matthew Lawrence, R. H.Keith Morris, Naresh Thirumalai, Roger Munro, Lisa Wakeman, Andrew Beddel, P. Rhodri Williams, Matthew Barrow, Daniel Curtis, M. Rowan Brown, Karl Hawkins^*

^*Corresponding author for this work

Cardiff School of Sport and Health Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

This study reports an automated numerical method for the location of the gel point in oscillatory shear data and demonstrates its potential application in measurements on therapeutically modified (heparinised) samples of healthy coagulating blood. Heparin prolongs the onset of clot formation and has a significant effect on the microstructure of the clot which is eventually formed. The results demonstrate the potential of this rheometrical technique as a new tool for monitoring the effect of heparin on samples of whole blood with significantly better linearity of response within the therapeutic range than another global coagulation monitoring technique (thromboelastography) which has previously been used.

Original language	English
Pages (from-to)	901-908
Number of pages	8
Journal	Rheologica Acta
Volume	49
Issue number	9
DOIs	https://doi.org/10.1007/s00397-010-0472-7
Publication status	Published - 25 Jul 2010

Keywords

Anti-coagulant
Fractal dimension
Incipient clot
Rheometry

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Evans, P. A., Lawrence, M., Morris, R. H. K., Thirumalai, N., Munro, R., Wakeman, L., Beddel, A., Williams, P. R., Barrow, M., Curtis, D., Brown, M. R., & Hawkins, K. (2010). Fractal analysis of viscoelastic data with automated gel point location and its potential application in the investigation of therapeutically modified blood coagulation. Rheologica Acta, 49(9), 901-908. https://doi.org/10.1007/s00397-010-0472-7

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title = "Fractal analysis of viscoelastic data with automated gel point location and its potential application in the investigation of therapeutically modified blood coagulation",

abstract = "This study reports an automated numerical method for the location of the gel point in oscillatory shear data and demonstrates its potential application in measurements on therapeutically modified (heparinised) samples of healthy coagulating blood. Heparin prolongs the onset of clot formation and has a significant effect on the microstructure of the clot which is eventually formed. The results demonstrate the potential of this rheometrical technique as a new tool for monitoring the effect of heparin on samples of whole blood with significantly better linearity of response within the therapeutic range than another global coagulation monitoring technique (thromboelastography) which has previously been used.",

keywords = "Anti-coagulant, Fractal dimension, Incipient clot, Rheometry",

author = "Evans, {P. Adrian} and Matthew Lawrence and Morris, {R. H.Keith} and Naresh Thirumalai and Roger Munro and Lisa Wakeman and Andrew Beddel and Williams, {P. Rhodri} and Matthew Barrow and Daniel Curtis and Brown, {M. Rowan} and Karl Hawkins",

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Evans, PA, Lawrence, M, Morris, RHK, Thirumalai, N, Munro, R, Wakeman, L, Beddel, A, Williams, PR, Barrow, M, Curtis, D, Brown, MR & Hawkins, K 2010, 'Fractal analysis of viscoelastic data with automated gel point location and its potential application in the investigation of therapeutically modified blood coagulation', Rheologica Acta, vol. 49, no. 9, pp. 901-908. https://doi.org/10.1007/s00397-010-0472-7

TY - JOUR

T1 - Fractal analysis of viscoelastic data with automated gel point location and its potential application in the investigation of therapeutically modified blood coagulation

AU - Evans, P. Adrian

AU - Lawrence, Matthew

AU - Morris, R. H.Keith

AU - Thirumalai, Naresh

AU - Munro, Roger

AU - Wakeman, Lisa

AU - Beddel, Andrew

AU - Williams, P. Rhodri

AU - Barrow, Matthew

AU - Curtis, Daniel

AU - Brown, M. Rowan

AU - Hawkins, Karl

PY - 2010/7/25

Y1 - 2010/7/25

N2 - This study reports an automated numerical method for the location of the gel point in oscillatory shear data and demonstrates its potential application in measurements on therapeutically modified (heparinised) samples of healthy coagulating blood. Heparin prolongs the onset of clot formation and has a significant effect on the microstructure of the clot which is eventually formed. The results demonstrate the potential of this rheometrical technique as a new tool for monitoring the effect of heparin on samples of whole blood with significantly better linearity of response within the therapeutic range than another global coagulation monitoring technique (thromboelastography) which has previously been used.

AB - This study reports an automated numerical method for the location of the gel point in oscillatory shear data and demonstrates its potential application in measurements on therapeutically modified (heparinised) samples of healthy coagulating blood. Heparin prolongs the onset of clot formation and has a significant effect on the microstructure of the clot which is eventually formed. The results demonstrate the potential of this rheometrical technique as a new tool for monitoring the effect of heparin on samples of whole blood with significantly better linearity of response within the therapeutic range than another global coagulation monitoring technique (thromboelastography) which has previously been used.

KW - Anti-coagulant

KW - Fractal dimension

KW - Incipient clot

KW - Rheometry

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U2 - 10.1007/s00397-010-0472-7

DO - 10.1007/s00397-010-0472-7

M3 - Article

AN - SCOPUS:77956177149

SN - 0035-4511

VL - 49

SP - 901

EP - 908

JO - Rheologica Acta

JF - Rheologica Acta

IS - 9

ER -

Fractal analysis of viscoelastic data with automated gel point location and its potential application in the investigation of therapeutically modified blood coagulation

Abstract

Keywords

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