Exploring autonomic nervous system dysfunction in patients with cancer cachexia: A pilot study

Alpna Chauhan; Ashika Sequeria; Cathann Manderson; Matthew Maddocks; David Wasley; Andrew Wilcock

doi:10.1016/j.autneu.2011.09.006

Exploring autonomic nervous system dysfunction in patients with cancer cachexia: A pilot study

Alpna Chauhan
, Ashika Sequeria
, Cathann Manderson
, Matthew Maddocks
, David Wasley
, Andrew Wilcock^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Introduction: Abnormalities of the autonomic nervous system (ANS) have been associated with cachexia. Methods: In nine cancer patients who had lost weight and nine age-matched healthy volunteers heart rate variability (HRV) components were determined, together with serum cortisol and urinary catecholamines/metanephrines. Results: Compared to volunteers, patients exhibited a global reduction in HRV parameters, significantly so for high frequency, low frequency and total power (median values ms ² 103 vs. 313, 62 vs. 148 and 316 vs. 736 respectively, P<0.05). Biochemical values did not differ. Conclusion: Our results suggest the presence of ANS dysfunction in patients with cancer cachexia, with reduction in both sympathetic and parasympathetic components.

Original language	English
Pages (from-to)	93-95
Number of pages	3
Journal	Autonomic Neuroscience: Basic and Clinical
Volume	166
Issue number	1-2
DOIs	https://doi.org/10.1016/j.autneu.2011.09.006
Publication status	Published - 19 Oct 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Autonomic nervous system
Cancer cachexia
Heart rate variability

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10.1016/j.autneu.2011.09.006

Cite this

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title = "Exploring autonomic nervous system dysfunction in patients with cancer cachexia: A pilot study",

abstract = "Introduction: Abnormalities of the autonomic nervous system (ANS) have been associated with cachexia. Methods: In nine cancer patients who had lost weight and nine age-matched healthy volunteers heart rate variability (HRV) components were determined, together with serum cortisol and urinary catecholamines/metanephrines. Results: Compared to volunteers, patients exhibited a global reduction in HRV parameters, significantly so for high frequency, low frequency and total power (median values ms 2 103 vs. 313, 62 vs. 148 and 316 vs. 736 respectively, P<0.05). Biochemical values did not differ. Conclusion: Our results suggest the presence of ANS dysfunction in patients with cancer cachexia, with reduction in both sympathetic and parasympathetic components.",

keywords = "Autonomic nervous system, Cancer cachexia, Heart rate variability",

author = "Alpna Chauhan and Ashika Sequeria and Cathann Manderson and Matthew Maddocks and David Wasley and Andrew Wilcock",

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TY - JOUR

T1 - Exploring autonomic nervous system dysfunction in patients with cancer cachexia

T2 - A pilot study

AU - Chauhan, Alpna

AU - Sequeria, Ashika

AU - Manderson, Cathann

AU - Maddocks, Matthew

AU - Wasley, David

AU - Wilcock, Andrew

PY - 2011/10/19

Y1 - 2011/10/19

N2 - Introduction: Abnormalities of the autonomic nervous system (ANS) have been associated with cachexia. Methods: In nine cancer patients who had lost weight and nine age-matched healthy volunteers heart rate variability (HRV) components were determined, together with serum cortisol and urinary catecholamines/metanephrines. Results: Compared to volunteers, patients exhibited a global reduction in HRV parameters, significantly so for high frequency, low frequency and total power (median values ms 2 103 vs. 313, 62 vs. 148 and 316 vs. 736 respectively, P<0.05). Biochemical values did not differ. Conclusion: Our results suggest the presence of ANS dysfunction in patients with cancer cachexia, with reduction in both sympathetic and parasympathetic components.

AB - Introduction: Abnormalities of the autonomic nervous system (ANS) have been associated with cachexia. Methods: In nine cancer patients who had lost weight and nine age-matched healthy volunteers heart rate variability (HRV) components were determined, together with serum cortisol and urinary catecholamines/metanephrines. Results: Compared to volunteers, patients exhibited a global reduction in HRV parameters, significantly so for high frequency, low frequency and total power (median values ms 2 103 vs. 313, 62 vs. 148 and 316 vs. 736 respectively, P<0.05). Biochemical values did not differ. Conclusion: Our results suggest the presence of ANS dysfunction in patients with cancer cachexia, with reduction in both sympathetic and parasympathetic components.

KW - Autonomic nervous system

KW - Cancer cachexia

KW - Heart rate variability

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DO - 10.1016/j.autneu.2011.09.006

M3 - Article

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AN - SCOPUS:84855916051

SN - 1566-0702

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JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

IS - 1-2

ER -

Exploring autonomic nervous system dysfunction in patients with cancer cachexia: A pilot study

Abstract

UN SDGs

Keywords

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