TY - JOUR
T1 - Exploring autonomic nervous system dysfunction in patients with cancer cachexia
T2 - A pilot study
AU - Chauhan, Alpna
AU - Sequeria, Ashika
AU - Manderson, Cathann
AU - Maddocks, Matthew
AU - Wasley, David
AU - Wilcock, Andrew
PY - 2011/10/19
Y1 - 2011/10/19
N2 - Introduction: Abnormalities of the autonomic nervous system (ANS) have been associated with cachexia. Methods: In nine cancer patients who had lost weight and nine age-matched healthy volunteers heart rate variability (HRV) components were determined, together with serum cortisol and urinary catecholamines/metanephrines. Results: Compared to volunteers, patients exhibited a global reduction in HRV parameters, significantly so for high frequency, low frequency and total power (median values ms 2 103 vs. 313, 62 vs. 148 and 316 vs. 736 respectively, P<0.05). Biochemical values did not differ. Conclusion: Our results suggest the presence of ANS dysfunction in patients with cancer cachexia, with reduction in both sympathetic and parasympathetic components.
AB - Introduction: Abnormalities of the autonomic nervous system (ANS) have been associated with cachexia. Methods: In nine cancer patients who had lost weight and nine age-matched healthy volunteers heart rate variability (HRV) components were determined, together with serum cortisol and urinary catecholamines/metanephrines. Results: Compared to volunteers, patients exhibited a global reduction in HRV parameters, significantly so for high frequency, low frequency and total power (median values ms 2 103 vs. 313, 62 vs. 148 and 316 vs. 736 respectively, P<0.05). Biochemical values did not differ. Conclusion: Our results suggest the presence of ANS dysfunction in patients with cancer cachexia, with reduction in both sympathetic and parasympathetic components.
KW - Autonomic nervous system
KW - Cancer cachexia
KW - Heart rate variability
UR - http://www.scopus.com/inward/record.url?scp=84855916051&partnerID=8YFLogxK
U2 - 10.1016/j.autneu.2011.09.006
DO - 10.1016/j.autneu.2011.09.006
M3 - Article
C2 - 22014539
AN - SCOPUS:84855916051
SN - 1566-0702
VL - 166
SP - 93
EP - 95
JO - Autonomic Neuroscience: Basic and Clinical
JF - Autonomic Neuroscience: Basic and Clinical
IS - 1-2
ER -
