TY - JOUR
T1 - Effects of strontium-containing fluorophosphate glasses for enhancing bioactivity and enamel remineralization
AU - Dhivya, V.
AU - Mahalaxmi, S.
AU - Rajkumar, K.
AU - Premkumar, V. V.
AU - Saravanakarthikeyan, B.
AU - Karpagam, R.
AU - Priyatharshini, R.
AU - Sakthipandi, K.
AU - Saikumari, V.
AU - Vijay, N.
AU - Rajkumar, G.
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/10/5
Y1 - 2021/10/5
N2 - The effect of strontium on the structure, apatite-forming ability, bioactivity, and enamel remineralization capability of 48P2O5-29CaO-3CaF2-(20-x)Na2O-xSrO fluorophosphate glasses (FPGs) was investigated. The apatite-forming ability of the SrFP samples was assessed by immersing them in simulated body fluid (SBF) solution for 21 days. X-ray diffractometer, Fourier transform infrared (FTIR) spectrometer, X-ray photon spectrometer, and scanning electron microscope coupled with energy-dispersive X-ray spectrometer were used to analyze the structural variation and apatite-forming capability of all the SrFP samples before and after being soaked in SBF solution. Cytotoxicity studies of the prepared samples were conducted by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay using human osteoblast-like MG-63 cell lines. It was found that 6 mol% Sr-doped FPGs has the better apatite-forming ability, increased cell viability, and enhanced bioactivity out of all the prepared glass samples. The remineralization efficacy of 6 mol% Sr-doped FPGs was evident from greater mineral deposits and increased microhardness values on teeth surface while compared to those of commercially available silica-based glass gel. The results obtained from the investigation showed that the glass sample containing 6 mol% of SrO content could be beneficial in therapeutic applications of teeth and bone tissue regeneration.
AB - The effect of strontium on the structure, apatite-forming ability, bioactivity, and enamel remineralization capability of 48P2O5-29CaO-3CaF2-(20-x)Na2O-xSrO fluorophosphate glasses (FPGs) was investigated. The apatite-forming ability of the SrFP samples was assessed by immersing them in simulated body fluid (SBF) solution for 21 days. X-ray diffractometer, Fourier transform infrared (FTIR) spectrometer, X-ray photon spectrometer, and scanning electron microscope coupled with energy-dispersive X-ray spectrometer were used to analyze the structural variation and apatite-forming capability of all the SrFP samples before and after being soaked in SBF solution. Cytotoxicity studies of the prepared samples were conducted by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay using human osteoblast-like MG-63 cell lines. It was found that 6 mol% Sr-doped FPGs has the better apatite-forming ability, increased cell viability, and enhanced bioactivity out of all the prepared glass samples. The remineralization efficacy of 6 mol% Sr-doped FPGs was evident from greater mineral deposits and increased microhardness values on teeth surface while compared to those of commercially available silica-based glass gel. The results obtained from the investigation showed that the glass sample containing 6 mol% of SrO content could be beneficial in therapeutic applications of teeth and bone tissue regeneration.
KW - Apatite
KW - Bioactive glass
KW - Bioactivity
KW - Enamel remineralization
KW - Glass melting
KW - Phosphates
UR - http://www.scopus.com/inward/record.url?scp=85116122866&partnerID=8YFLogxK
U2 - 10.1016/j.matchar.2021.111496
DO - 10.1016/j.matchar.2021.111496
M3 - Article
AN - SCOPUS:85116122866
SN - 1044-5803
VL - 181
JO - Materials Characterization
JF - Materials Characterization
M1 - 111496
ER -