TY - JOUR
T1 - Effects of 6months glucagon-like peptide-1 receptor agonist treatment on endothelial function in type 2 diabetes mellitus patients
AU - Hopkins, N. D.
AU - Cuthbertson, D. J.
AU - Kemp, G. J.
AU - Pugh, C.
AU - Green, D. J.
AU - Cable, N. T.
AU - Jones, H.
PY - 2013/3/1
Y1 - 2013/3/1
N2 - Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are used for treatment in type 2 diabetes mellitus (T2DM). Little is known about their cardiovascular (CV) impact. We sought to determine the effects of chronic treatment on vascular function in T2DM. Brachial artery endothelial-dependent flow-mediated dilation (FMD) and endothelial-independent glyceryl trinitrate (GTN) function and carotid intima-medial thickness (cIMT) were assessed in 11 severely obese T2DMs (4 females, 7 males: 55±8years, diabetes duration 8.3±4.7years mean±s.d.) before and after 6months GLP-1 RA. Body weight (5.3±1.2kg; p<0.05) and magnetic resonance imaging determined total and subcutaneous fat, but not visceral fat, decreased. Glycaemic control improved. There were no significant changes in FMD, GTN and cIMT (-1.1±0.4%, 0.3±3.0% and 0.00±0.04mm, respectively). Despite significant improvements in body composition and glycaemic control, 6months GLP-1 RA treatment did not modulate vascular function. Alternative strategies may therefore be needed to reduce the burden of CV risk in severely obese patients with long-standing T2DM.
AB - Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are used for treatment in type 2 diabetes mellitus (T2DM). Little is known about their cardiovascular (CV) impact. We sought to determine the effects of chronic treatment on vascular function in T2DM. Brachial artery endothelial-dependent flow-mediated dilation (FMD) and endothelial-independent glyceryl trinitrate (GTN) function and carotid intima-medial thickness (cIMT) were assessed in 11 severely obese T2DMs (4 females, 7 males: 55±8years, diabetes duration 8.3±4.7years mean±s.d.) before and after 6months GLP-1 RA. Body weight (5.3±1.2kg; p<0.05) and magnetic resonance imaging determined total and subcutaneous fat, but not visceral fat, decreased. Glycaemic control improved. There were no significant changes in FMD, GTN and cIMT (-1.1±0.4%, 0.3±3.0% and 0.00±0.04mm, respectively). Despite significant improvements in body composition and glycaemic control, 6months GLP-1 RA treatment did not modulate vascular function. Alternative strategies may therefore be needed to reduce the burden of CV risk in severely obese patients with long-standing T2DM.
KW - Carotid intima-medial thickness
KW - Endothelial function
KW - GLP-1 receptor agonists
KW - Obesity
KW - Type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=84879795191&partnerID=8YFLogxK
U2 - 10.1111/dom.12089
DO - 10.1111/dom.12089
M3 - Article
C2 - 23451821
AN - SCOPUS:84879795191
SN - 1462-8902
VL - 15
SP - 770
EP - 773
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
IS - 8
ER -