Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141

Rebecca Aicheler; Eddie Wang; Andrew Davidson; Borivoj Vojtesek; Melanie  Armstrong; Cora Griffin; Brian McSharry; Sian Llewellyn-Lacey; Carole Rickards; Akio Nomoto; Christian Sinzger; Gavin Wilkinson

doi:10.1038/ni1156

Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141

Rebecca Aicheler, Eddie Wang, Andrew Davidson, Borivoj Vojtesek, Melanie Armstrong, Cora Griffin, Brian McSharry, Sian Llewellyn-Lacey, Carole Rickards, Akio Nomoto, Christian Sinzger, Gavin Wilkinson

Research output: Contribution to journal › Article › peer-review

Abstract

Natural killer (NK) cells are crucial in the control of cytomegalovirus infections in mice and humans. Here we show that the viral UL141 gene product has an immunomodulatory function that is associated with low-passage strains of human cytomegalovirus. UL141 mediated efficient protection of cells against killing by a wide range of human NK cell populations, including interferon-alpha-stimulated bulk cultures, polyclonal NK cell lines and most NK cell clones tested. Evasion of NK cell killing was mediated by UL141 blocking surface expression of CD155, which was previously identified as a ligand for NK cell-activating receptors CD226 (DNAM-1) and CD96 (TACTILE). The breadth of the UL141-mediated effect indicates that CD155 has a key role in regulating NK cell function.

Original language	English
Journal	Nature Immunology
DOIs	https://doi.org/10.1038/ni1156
Publication status	Published - 9 Jan 2005
Externally published	Yes

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10.1038/ni1156

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title = "Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141",

abstract = "Natural killer (NK) cells are crucial in the control of cytomegalovirus infections in mice and humans. Here we show that the viral UL141 gene product has an immunomodulatory function that is associated with low-passage strains of human cytomegalovirus. UL141 mediated efficient protection of cells against killing by a wide range of human NK cell populations, including interferon-alpha-stimulated bulk cultures, polyclonal NK cell lines and most NK cell clones tested. Evasion of NK cell killing was mediated by UL141 blocking surface expression of CD155, which was previously identified as a ligand for NK cell-activating receptors CD226 (DNAM-1) and CD96 (TACTILE). The breadth of the UL141-mediated effect indicates that CD155 has a key role in regulating NK cell function.",

author = "Rebecca Aicheler and Eddie Wang and Andrew Davidson and Borivoj Vojtesek and Melanie Armstrong and Cora Griffin and Brian McSharry and Sian Llewellyn-Lacey and Carole Rickards and Akio Nomoto and Christian Sinzger and Gavin Wilkinson",

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doi = "10.1038/ni1156",

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T1 - Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141

AU - Aicheler, Rebecca

AU - Wang, Eddie

AU - Davidson, Andrew

AU - Vojtesek, Borivoj

AU - Armstrong, Melanie

AU - Griffin, Cora

AU - McSharry, Brian

AU - Llewellyn-Lacey, Sian

AU - Rickards, Carole

AU - Nomoto, Akio

AU - Sinzger, Christian

AU - Wilkinson, Gavin

PY - 2005/1/9

Y1 - 2005/1/9

N2 - Natural killer (NK) cells are crucial in the control of cytomegalovirus infections in mice and humans. Here we show that the viral UL141 gene product has an immunomodulatory function that is associated with low-passage strains of human cytomegalovirus. UL141 mediated efficient protection of cells against killing by a wide range of human NK cell populations, including interferon-alpha-stimulated bulk cultures, polyclonal NK cell lines and most NK cell clones tested. Evasion of NK cell killing was mediated by UL141 blocking surface expression of CD155, which was previously identified as a ligand for NK cell-activating receptors CD226 (DNAM-1) and CD96 (TACTILE). The breadth of the UL141-mediated effect indicates that CD155 has a key role in regulating NK cell function.

AB - Natural killer (NK) cells are crucial in the control of cytomegalovirus infections in mice and humans. Here we show that the viral UL141 gene product has an immunomodulatory function that is associated with low-passage strains of human cytomegalovirus. UL141 mediated efficient protection of cells against killing by a wide range of human NK cell populations, including interferon-alpha-stimulated bulk cultures, polyclonal NK cell lines and most NK cell clones tested. Evasion of NK cell killing was mediated by UL141 blocking surface expression of CD155, which was previously identified as a ligand for NK cell-activating receptors CD226 (DNAM-1) and CD96 (TACTILE). The breadth of the UL141-mediated effect indicates that CD155 has a key role in regulating NK cell function.

U2 - 10.1038/ni1156

DO - 10.1038/ni1156

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JO - Nature Immunology

JF - Nature Immunology

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