TY - JOUR
T1 - Clusters of risk factors in metabolic syndrome and their influence on central blood pressure in a global study
AU - Laucyte-Cibulskiene, Agne
AU - Chen, Chen Huan
AU - Cockroft, John
AU - Cunha, Pedro G.
AU - Kavousi, Maryam
AU - Laucevicius, Aleksandras
AU - Muiesan, Maria Lorenza
AU - Rietzschel, Ernst R.
AU - Ryliskyte, Ligita
AU - Strazhesko, Irina D.
AU - Vlachopoulos, Charalambos
AU - Cotter, Jorge
AU - Dudinskaya, Ekatherina N.
AU - Gale, Nichola
AU - Ahmadizar, Fariba
AU - Mattace-Raso, Francesco U.S.
AU - Munnery, Maggie
AU - Oliveira, Pedro
AU - Paini, Anna
AU - Salvetti, Massimo
AU - Tkacheva, Olga N.
AU - Lakatta, Edward G.
AU - Nilsson, Peter M.
AU - Scuteri, Angelo
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/8/24
Y1 - 2022/8/24
N2 - The effect of metabolic syndrome (MetS) and clusters of its components on central blood pressure (CBP) has not been well characterized. We aimed to describe the effect of MetS and clusters of its components on CBP in a large population and to identify whether this effect differs in men and women. We studied 15,609 volunteers (43% women) from 10 cohorts worldwide who participated in the Metabolic syndrome and Artery REsearch Consortium. MetS was defined according to the NCEP-ATP III criteria (GHTBW, glucose, high-density lipoprotein cholesterol, triglyceride, blood pressure, waist circumference). CBP was measured noninvasively and acquired from pulse wave analysis by applanation tonometry. MetS was associated with a 50% greater odds of having higher CSBP. After controlling for age, male sex, non HDL cholesterol, diabetes mellitus, and mean arterial pressure, only specific clusters of MetS components were associated with a higher CSBP; and some of them were significant in women but not in men. We identified “risky clusters” of MetS variables associated with high CSBP. Future studies are needed to confirm they identify subjects at high risk of accelerated arterial aging and, thus, need more intensive clinical management.
AB - The effect of metabolic syndrome (MetS) and clusters of its components on central blood pressure (CBP) has not been well characterized. We aimed to describe the effect of MetS and clusters of its components on CBP in a large population and to identify whether this effect differs in men and women. We studied 15,609 volunteers (43% women) from 10 cohorts worldwide who participated in the Metabolic syndrome and Artery REsearch Consortium. MetS was defined according to the NCEP-ATP III criteria (GHTBW, glucose, high-density lipoprotein cholesterol, triglyceride, blood pressure, waist circumference). CBP was measured noninvasively and acquired from pulse wave analysis by applanation tonometry. MetS was associated with a 50% greater odds of having higher CSBP. After controlling for age, male sex, non HDL cholesterol, diabetes mellitus, and mean arterial pressure, only specific clusters of MetS components were associated with a higher CSBP; and some of them were significant in women but not in men. We identified “risky clusters” of MetS variables associated with high CSBP. Future studies are needed to confirm they identify subjects at high risk of accelerated arterial aging and, thus, need more intensive clinical management.
UR - http://www.scopus.com/inward/record.url?scp=85136486138&partnerID=8YFLogxK
U2 - 10.1038/s41598-022-18094-y
DO - 10.1038/s41598-022-18094-y
M3 - Article
C2 - 36002468
AN - SCOPUS:85136486138
SN - 2045-2322
VL - 12
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 14409
ER -
