Chlorhexidine hexametaphosphate as a wound care material coating: Antimicrobial efficacy, toxicity and effect on healing

Michele E. Barbour; Sarah E. Maddocks; Helena J. Grady; James A. Roper; Mark D. Bass; Andrew M. Collins; Rachel M. Dommett; Margaret Saunders

doi:10.2217/nnm-2016-0084

Chlorhexidine hexametaphosphate as a wound care material coating: Antimicrobial efficacy, toxicity and effect on healing

Michele E. Barbour^*, Sarah E. Maddocks, Helena J. Grady, James A. Roper, Mark D. Bass, Andrew M. Collins, Rachel M. Dommett, Margaret Saunders

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Aim: In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials & methods: CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Results: Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by E. faecalis. Conclusion: CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure.

Original language	English
Pages (from-to)	2049-2057
Number of pages	9
Journal	Nanomedicine
Volume	11
Issue number	16
DOIs	https://doi.org/10.2217/nnm-2016-0084
Publication status	Published - 28 Jul 2016

Keywords

antimicrobial
catheter
chlorhexidine
healing
safety
toxicity
wound care

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title = "Chlorhexidine hexametaphosphate as a wound care material coating: Antimicrobial efficacy, toxicity and effect on healing",

abstract = "Aim: In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials & methods: CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Results: Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by E. faecalis. Conclusion: CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure.",

keywords = "antimicrobial, catheter, chlorhexidine, healing, safety, toxicity, wound care",

author = "Barbour, {Michele E.} and Maddocks, {Sarah E.} and Grady, {Helena J.} and Roper, {James A.} and Bass, {Mark D.} and Collins, {Andrew M.} and Dommett, {Rachel M.} and Margaret Saunders",

note = "Publisher Copyright: {\textcopyright} 2016 Michele Barbour.",

year = "2016",

month = jul,

day = "28",

doi = "10.2217/nnm-2016-0084",

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volume = "11",

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T1 - Chlorhexidine hexametaphosphate as a wound care material coating

T2 - Antimicrobial efficacy, toxicity and effect on healing

AU - Barbour, Michele E.

AU - Maddocks, Sarah E.

AU - Grady, Helena J.

AU - Roper, James A.

AU - Bass, Mark D.

AU - Collins, Andrew M.

AU - Dommett, Rachel M.

AU - Saunders, Margaret

PY - 2016/7/28

Y1 - 2016/7/28

N2 - Aim: In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials & methods: CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Results: Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by E. faecalis. Conclusion: CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure.

AB - Aim: In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials & methods: CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Results: Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by E. faecalis. Conclusion: CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure.

KW - antimicrobial

KW - catheter

KW - chlorhexidine

KW - healing

KW - safety

KW - toxicity

KW - wound care

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DO - 10.2217/nnm-2016-0084

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AN - SCOPUS:84982161009

SN - 1743-5889

VL - 11

SP - 2049

EP - 2057

JO - Nanomedicine

JF - Nanomedicine

IS - 16

ER -

Chlorhexidine hexametaphosphate as a wound care material coating: Antimicrobial efficacy, toxicity and effect on healing

Abstract

Keywords

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