A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase

Friederike I. Nollmann; Antje K. Heinrich; Alexander O. Brachmann; Christophe Morisseau; Krishnendu Mukherjee; Ángel M. Casanova-Torres; Frederic Strobl; David Kleinhans; Sebastian Kinski; Katharina Schultz; Michael L. Beeton; Marcel Kaiser; Ya Yun Chu; Long Phan Ke; Aunchalee Thanwisai; Kenan A.J. Bozhüyük; Narisara Chantratita; Friedrich Götz; Nick R. Waterfield; Andreas Vilcinskas; Ernst H.K. Stelzer; Heidi Goodrich-Blair; Bruce D. Hammock; Helge B. Bode

doi:10.1002/cbic.201402650

A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase

Friederike I. Nollmann, Antje K. Heinrich, Alexander O. Brachmann, Christophe Morisseau, Krishnendu Mukherjee, Ángel M. Casanova-Torres, Frederic Strobl, David Kleinhans, Sebastian Kinski, Katharina Schultz, Michael L. Beeton, Marcel Kaiser, Ya Yun Chu, Long Phan Ke, Aunchalee Thanwisai, Kenan A.J. Bozhüyük, Narisara Chantratita, Friedrich Götz, Nick R. Waterfield, Andreas VilcinskasErnst H.K. Stelzer, Heidi Goodrich-Blair, Bruce D. Hammock, Helge B. Bode^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.

Original language	English
Pages (from-to)	766-771
Number of pages	6
Journal	ChemBioChem
Volume	16
Issue number	5
DOIs	https://doi.org/10.1002/cbic.201402650
Publication status	Published - 25 Feb 2015

Keywords

Photorhabdus
biosynthesis
entomopathogenic bacteria
juvenile hormone epoxide hydrolase inhibitor
natural products

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Nollmann, F. I., Heinrich, A. K., Brachmann, A. O., Morisseau, C., Mukherjee, K., Casanova-Torres, Á. M., Strobl, F., Kleinhans, D., Kinski, S., Schultz, K., Beeton, M. L., Kaiser, M., Chu, Y. Y., Phan Ke, L., Thanwisai, A., Bozhüyük, K. A. J., Chantratita, N., Götz, F., Waterfield, N. R., ... Bode, H. B. (2015). A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. ChemBioChem, 16(5), 766-771. https://doi.org/10.1002/cbic.201402650

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abstract = "Simple urea compounds ({"}phurealipids{"}) have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.",

keywords = "Photorhabdus, biosynthesis, entomopathogenic bacteria, juvenile hormone epoxide hydrolase inhibitor, natural products",

author = "Nollmann, {Friederike I.} and Heinrich, {Antje K.} and Brachmann, {Alexander O.} and Christophe Morisseau and Krishnendu Mukherjee and Casanova-Torres, {{\'A}ngel M.} and Frederic Strobl and David Kleinhans and Sebastian Kinski and Katharina Schultz and Beeton, {Michael L.} and Marcel Kaiser and Chu, {Ya Yun} and {Phan Ke}, Long and Aunchalee Thanwisai and Bozh{\"u}y{\"u}k, {Kenan A.J.} and Narisara Chantratita and Friedrich G{\"o}tz and Waterfield, {Nick R.} and Andreas Vilcinskas and Stelzer, {Ernst H.K.} and Heidi Goodrich-Blair and Hammock, {Bruce D.} and Bode, {Helge B.}",

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year = "2015",

month = feb,

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doi = "10.1002/cbic.201402650",

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Nollmann, FI, Heinrich, AK, Brachmann, AO, Morisseau, C, Mukherjee, K, Casanova-Torres, ÁM, Strobl, F, Kleinhans, D, Kinski, S, Schultz, K, Beeton, ML, Kaiser, M, Chu, YY, Phan Ke, L, Thanwisai, A, Bozhüyük, KAJ, Chantratita, N, Götz, F, Waterfield, NR, Vilcinskas, A, Stelzer, EHK, Goodrich-Blair, H, Hammock, BD & Bode, HB 2015, 'A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase', ChemBioChem, vol. 16, no. 5, pp. 766-771. https://doi.org/10.1002/cbic.201402650

TY - JOUR

T1 - A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase

AU - Nollmann, Friederike I.

AU - Heinrich, Antje K.

AU - Brachmann, Alexander O.

AU - Morisseau, Christophe

AU - Mukherjee, Krishnendu

AU - Casanova-Torres, Ángel M.

AU - Strobl, Frederic

AU - Kleinhans, David

AU - Kinski, Sebastian

AU - Schultz, Katharina

AU - Beeton, Michael L.

AU - Kaiser, Marcel

AU - Chu, Ya Yun

AU - Phan Ke, Long

AU - Thanwisai, Aunchalee

AU - Bozhüyük, Kenan A.J.

AU - Chantratita, Narisara

AU - Götz, Friedrich

AU - Waterfield, Nick R.

AU - Vilcinskas, Andreas

AU - Stelzer, Ernst H.K.

AU - Goodrich-Blair, Heidi

AU - Hammock, Bruce D.

AU - Bode, Helge B.

PY - 2015/2/25

Y1 - 2015/2/25

N2 - Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.

AB - Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.

KW - Photorhabdus

KW - biosynthesis

KW - entomopathogenic bacteria

KW - juvenile hormone epoxide hydrolase inhibitor

KW - natural products

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SP - 766

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JO - ChemBioChem

JF - ChemBioChem

IS - 5

ER -

A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase

Abstract

Keywords

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