A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

Matthew J. Lawrence; Ahmed Sabra; Gavin Mills; Suresh G. Pillai; Wendy Abdullah; Karl Hawkins; Roger H.K. Morris; Simon J. Davidson; Lindsay A. D'Silva; Daniel J. Curtis; Martin R. Brown; John W. Weisel; Phylip R. Williams; Phillip A. Evans

doi:10.1111/bjh.13173

A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

Matthew J. Lawrence
, Ahmed Sabra
, Gavin Mills
, Suresh G. Pillai
, Wendy Abdullah
, Karl Hawkins
, Roger H.K. Morris
, Simon J. Davidson
, Lindsay A. D'Silva
, Daniel J. Curtis
, Martin R. Brown
, John W. Weisel
, Phylip R. Williams
, Phillip A. Evans^*

^*Corresponding author for this work

Cardiff School of Sport and Health Sciences

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

4 Downloads (Pure)

Abstract

Summary: This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (d_f) and clot formation time (T_GP). d_f was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The 'abnormal' clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of d_f in first time VTE patients who later develop a secondary event indicates that d_f may identify those at risk of recurrence.

Original language	English
Pages (from-to)	571-575
Number of pages	5
Journal	British Journal of Haematology
Volume	168
Issue number	4
DOIs	https://doi.org/10.1111/bjh.13173
Publication status	Published - 10 Oct 2014

Keywords

Anticoagulation
Blood coagulation
Haemostasis
Venous thrombosis
Warfarin

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10.1111/bjh.13173

A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism-Lawrence MAccepted author manuscript, 425 KBLicence: Under Copyright

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Lawrence, M. J., Sabra, A., Mills, G., Pillai, S. G., Abdullah, W., Hawkins, K., Morris, R. H. K., Davidson, S. J., D'Silva, L. A., Curtis, D. J., Brown, M. R., Weisel, J. W., Williams, P. R., & Evans, P. A. (2014). A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism. British Journal of Haematology, 168(4), 571-575. https://doi.org/10.1111/bjh.13173

@article{0e28847c24754986b1fb6fcbdc3fa2f3,

title = "A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism",

abstract = "Summary: This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The 'abnormal' clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence.",

keywords = "Anticoagulation, Blood coagulation, Haemostasis, Venous thrombosis, Warfarin",

author = "Lawrence, \{Matthew J.\} and Ahmed Sabra and Gavin Mills and Pillai, \{Suresh G.\} and Wendy Abdullah and Karl Hawkins and Morris, \{Roger H.K.\} and Davidson, \{Simon J.\} and D'Silva, \{Lindsay A.\} and Curtis, \{Daniel J.\} and Brown, \{Martin R.\} and Weisel, \{John W.\} and Williams, \{Phylip R.\} and Evans, \{Phillip A.\}",

note = "Publisher Copyright: {\textcopyright} 2014 John Wiley \& Sons Ltd.",

year = "2014",

month = oct,

day = "10",

doi = "10.1111/bjh.13173",

language = "English",

volume = "168",

pages = "571--575",

journal = "British Journal of Haematology",

issn = "0007-1048",

number = "4",

}

Lawrence, MJ, Sabra, A, Mills, G, Pillai, SG, Abdullah, W, Hawkins, K, Morris, RHK, Davidson, SJ, D'Silva, LA, Curtis, DJ, Brown, MR, Weisel, JW, Williams, PR & Evans, PA 2014, 'A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism', British Journal of Haematology, vol. 168, no. 4, pp. 571-575. https://doi.org/10.1111/bjh.13173

TY - JOUR

T1 - A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

AU - Lawrence, Matthew J.

AU - Sabra, Ahmed

AU - Mills, Gavin

AU - Pillai, Suresh G.

AU - Abdullah, Wendy

AU - Hawkins, Karl

AU - Morris, Roger H.K.

AU - Davidson, Simon J.

AU - D'Silva, Lindsay A.

AU - Curtis, Daniel J.

AU - Brown, Martin R.

AU - Weisel, John W.

AU - Williams, Phylip R.

AU - Evans, Phillip A.

PY - 2014/10/10

Y1 - 2014/10/10

N2 - Summary: This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The 'abnormal' clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence.

AB - Summary: This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The 'abnormal' clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence.

KW - Anticoagulation

KW - Blood coagulation

KW - Haemostasis

KW - Venous thrombosis

KW - Warfarin

UR - https://www.scopus.com/pages/publications/84923094213

U2 - 10.1111/bjh.13173

DO - 10.1111/bjh.13173

M3 - Article

C2 - 25302653

AN - SCOPUS:84923094213

SN - 0007-1048

VL - 168

SP - 571

EP - 575

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

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Keywords

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