A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

Matthew J. Lawrence; Ahmed Sabra; Gavin Mills; Suresh G. Pillai; Wendy Abdullah; Karl Hawkins; Roger H.K. Morris; Simon J. Davidson; Lindsay A. D'Silva; Daniel J. Curtis; Martin R. Brown; John W. Weisel; Phylip R. Williams; Phillip A. Evans

doi:10.1111/bjh.13173

A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

Matthew J. Lawrence, Ahmed Sabra, Gavin Mills, Suresh G. Pillai, Wendy Abdullah, Karl Hawkins, Roger H.K. Morris, Simon J. Davidson, Lindsay A. D'Silva, Daniel J. Curtis, Martin R. Brown, John W. Weisel, Phylip R. Williams, Phillip A. Evans^*

^*Corresponding author for this work

Cardiff School of Sport and Health Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Summary: This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (d_f) and clot formation time (T_GP). d_f was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The 'abnormal' clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of d_f in first time VTE patients who later develop a secondary event indicates that d_f may identify those at risk of recurrence.

Original language	English
Pages (from-to)	571-575
Number of pages	5
Journal	British Journal of Haematology
Volume	168
Issue number	4
DOIs	https://doi.org/10.1111/bjh.13173
Publication status	Published - 10 Oct 2014

Keywords

Anticoagulation
Blood coagulation
Haemostasis
Venous thrombosis
Warfarin

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10.1111/bjh.13173

A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism-Lawrence MAccepted author manuscript, 425 KBLicence: Under Copyright

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Lawrence, M. J., Sabra, A., Mills, G., Pillai, S. G., Abdullah, W., Hawkins, K., Morris, R. H. K., Davidson, S. J., D'Silva, L. A., Curtis, D. J., Brown, M. R., Weisel, J. W., Williams, P. R., & Evans, P. A. (2014). A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism. British Journal of Haematology, 168(4), 571-575. https://doi.org/10.1111/bjh.13173

@article{0e28847c24754986b1fb6fcbdc3fa2f3,

title = "A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism",

abstract = "Summary: This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The 'abnormal' clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence.",

keywords = "Anticoagulation, Blood coagulation, Haemostasis, Venous thrombosis, Warfarin",

author = "Lawrence, {Matthew J.} and Ahmed Sabra and Gavin Mills and Pillai, {Suresh G.} and Wendy Abdullah and Karl Hawkins and Morris, {Roger H.K.} and Davidson, {Simon J.} and D'Silva, {Lindsay A.} and Curtis, {Daniel J.} and Brown, {Martin R.} and Weisel, {John W.} and Williams, {Phylip R.} and Evans, {Phillip A.}",

note = "Publisher Copyright: {\textcopyright} 2014 John Wiley & Sons Ltd.",

year = "2014",

month = oct,

day = "10",

doi = "10.1111/bjh.13173",

language = "English",

volume = "168",

pages = "571--575",

journal = "British Journal of Haematology",

issn = "0007-1048",

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}

Lawrence, MJ, Sabra, A, Mills, G, Pillai, SG, Abdullah, W, Hawkins, K, Morris, RHK, Davidson, SJ, D'Silva, LA, Curtis, DJ, Brown, MR, Weisel, JW, Williams, PR & Evans, PA 2014, 'A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism', British Journal of Haematology, vol. 168, no. 4, pp. 571-575. https://doi.org/10.1111/bjh.13173

TY - JOUR

T1 - A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

AU - Lawrence, Matthew J.

AU - Sabra, Ahmed

AU - Mills, Gavin

AU - Pillai, Suresh G.

AU - Abdullah, Wendy

AU - Hawkins, Karl

AU - Morris, Roger H.K.

AU - Davidson, Simon J.

AU - D'Silva, Lindsay A.

AU - Curtis, Daniel J.

AU - Brown, Martin R.

AU - Weisel, John W.

AU - Williams, Phylip R.

AU - Evans, Phillip A.

PY - 2014/10/10

Y1 - 2014/10/10

N2 - Summary: This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The 'abnormal' clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence.

AB - Summary: This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The 'abnormal' clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence.

KW - Anticoagulation

KW - Blood coagulation

KW - Haemostasis

KW - Venous thrombosis

KW - Warfarin

UR - http://www.scopus.com/inward/record.url?scp=84923094213&partnerID=8YFLogxK

U2 - 10.1111/bjh.13173

DO - 10.1111/bjh.13173

M3 - Article

C2 - 25302653

AN - SCOPUS:84923094213

SN - 0007-1048

VL - 168

SP - 571

EP - 575

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

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