Organisation profile
Organisation profile
The Cellular and Molecular Pathophysiology R&I group undertakes research at the interface between biology and medicine focusing on the pathophysiology of ageing and cardiovascular diseases. Our research aims to advance the understanding of pathological processes, such as atherosclerosis and neurodegeneration, and is applicable to the risk stratification, diagnosis and treatment of common age-related conditions, including stroke, dementia and frailty. Group members have a breadth of expertise, encompassing classic cell and molecular biology, inflammation, cell senescence, vascular biology, biomarker analysis and bioinformatics, which they apply to interrogate in vitro models and clinical cohorts.
Collaborations and top research areas from the last five years
Profiles
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Maninder Ahluwalia
- Cardiff School of Sport and Health Sciences - Principal Lecturer in Clinical/Human Genetics
- ZERO2FIVE Food Industry Centre
- Centre for Cardiovascular Research, Innovation And Development (CURIAD)
- Cellular and Molecular Pathophysiology
- Food Safety & Nutrition
Person: Academic
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Lee Butcher
- Cardiff School of Sport and Health Sciences - Senior Lecturer in Biomedical Science
- Centre for Cardiovascular Research, Innovation And Development (CURIAD)
- Cellular and Molecular Pathophysiology
- Clinical Application and Translation
Person: Academic
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Computational Fluid Dynamic Analysis of Fluid Motion and Volumetric Gas-Liquid Mass Transfer in Agitated Platelet Concentrate Storage
Pym, D., Davies, A. J., Williams, J. O., Saunders, C., George, C. E., Mason-Jones, A. & James, P. E., 8 Jan 2026, In: Biotechnology journal. 21, 1, e70177.Research output: Contribution to journal › Article › peer-review
Open Access -
Hypoxia stimulates blood–brain barrier disruption and systemic appearance of pro-coagulant, brain-derived extracellular vesicles: Implications in transient ischaemic attack patients
Raven, R. M., Williams, J. O., Whelan, C., White, J., Morris, K., Geen, J. & James, P. E., 5 Feb 2026, In: Journal of Cerebral Blood Flow and Metabolism.Research output: Contribution to journal › Article › peer-review
Open Access -
Enhanced O 2 availability in platelet concentrates stored for neonatal transfusion is independent of agitation: Evidence from direct oximetry and Fickian diffusion modelling
Pym, D., Grinberg, O., Davies, A. J., Williams, J. O., Saunders, C., George, C. E. & James, P. E., 28 Aug 2025, In: Vox Sanguinis. 120, 12, p. 1232-1241 10 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus)