Role of adipocyte-derived extracellular vesicles in vascular inflammation

Katherine D. Connolly; D. Aled Rees; Philip E. James

doi:10.1016/j.freeradbiomed.2021.04.031

Role of adipocyte-derived extracellular vesicles in vascular inflammation

Katherine D. Connolly
, D. Aled Rees
, Philip E. James^*

^*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl adolygu › adolygiad gan gymheiriaid

19 Dyfyniadau (Scopus)

27 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

Extracellular vesicles (EVs) are nanometre-sized vesicles released from most cells, including adipocytes. Relatively little is known about adipocyte-derived EVs (ADEVs) in comparison to other EV subtypes, though interest in ADEVs as potential paracrine and endocrine communicators of adipose tissue in obesity is building. Current evidence indicates that ADEVs contribute to the development of adipose tissue dysfunction; a key feature of obese adipose tissue that it is associated with obesity-related comorbidities including cardiovascular disease (CVD). This review summarises our current knowledge of ADEVs in the development of adipose tissue dysfunction and the potential of ADEVs to disrupt redox signalling and exert vascular effects that may exacerbate CVD in obesity.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	58-64
Nifer y tudalennau	7
Cyfnodolyn	Free Radical Biology and Medicine
Cyfrol	172
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/j.freeradbiomed.2021.04.031
Statws	Cyhoeddwyd - 4 Meh 2021

NDC y CU

Mae’r allbwn hwn yn cyfrannu at y Nod(au) Datblygu Cynaliadwy canlynol

NDC 3 Iechyd a Llesiant Da

Mynediad at Ddogfen

10.1016/j.freeradbiomed.2021.04.031

FRBM Connolly et al_revised manuscriptLlawysgrif awdur wedi’i dderbyn, 311 KBTrwydded: CC BY-NC-ND

Ffeiliau eraill a chysylltiadau

Dolen i’r cyhoeddiad yn Scopus

Dyfynnu hyn

@article{da631e19031f41f0b1d5dc673d5fdae4,

title = "Role of adipocyte-derived extracellular vesicles in vascular inflammation",

abstract = "Extracellular vesicles (EVs) are nanometre-sized vesicles released from most cells, including adipocytes. Relatively little is known about adipocyte-derived EVs (ADEVs) in comparison to other EV subtypes, though interest in ADEVs as potential paracrine and endocrine communicators of adipose tissue in obesity is building. Current evidence indicates that ADEVs contribute to the development of adipose tissue dysfunction; a key feature of obese adipose tissue that it is associated with obesity-related comorbidities including cardiovascular disease (CVD). This review summarises our current knowledge of ADEVs in the development of adipose tissue dysfunction and the potential of ADEVs to disrupt redox signalling and exert vascular effects that may exacerbate CVD in obesity.",

keywords = "Adipocyte dysfunction, Adipocytes, Adipose tissue, Extracellular vesicles, Obesity, Vascular inflammation",

author = "Connolly, \{Katherine D.\} and Rees, \{D. Aled\} and James, \{Philip E.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = jun,

day = "4",

doi = "10.1016/j.freeradbiomed.2021.04.031",

language = "English",

volume = "172",

pages = "58--64",

journal = "Free Radical Biology and Medicine",

issn = "0891-5849",

}

TY - JOUR

T1 - Role of adipocyte-derived extracellular vesicles in vascular inflammation

AU - Connolly, Katherine D.

AU - Rees, D. Aled

AU - James, Philip E.

PY - 2021/6/4

Y1 - 2021/6/4

N2 - Extracellular vesicles (EVs) are nanometre-sized vesicles released from most cells, including adipocytes. Relatively little is known about adipocyte-derived EVs (ADEVs) in comparison to other EV subtypes, though interest in ADEVs as potential paracrine and endocrine communicators of adipose tissue in obesity is building. Current evidence indicates that ADEVs contribute to the development of adipose tissue dysfunction; a key feature of obese adipose tissue that it is associated with obesity-related comorbidities including cardiovascular disease (CVD). This review summarises our current knowledge of ADEVs in the development of adipose tissue dysfunction and the potential of ADEVs to disrupt redox signalling and exert vascular effects that may exacerbate CVD in obesity.

AB - Extracellular vesicles (EVs) are nanometre-sized vesicles released from most cells, including adipocytes. Relatively little is known about adipocyte-derived EVs (ADEVs) in comparison to other EV subtypes, though interest in ADEVs as potential paracrine and endocrine communicators of adipose tissue in obesity is building. Current evidence indicates that ADEVs contribute to the development of adipose tissue dysfunction; a key feature of obese adipose tissue that it is associated with obesity-related comorbidities including cardiovascular disease (CVD). This review summarises our current knowledge of ADEVs in the development of adipose tissue dysfunction and the potential of ADEVs to disrupt redox signalling and exert vascular effects that may exacerbate CVD in obesity.

KW - Adipocyte dysfunction

KW - Adipocytes

KW - Adipose tissue

KW - Extracellular vesicles

KW - Obesity

KW - Vascular inflammation

UR - https://www.scopus.com/pages/publications/85108176359

U2 - 10.1016/j.freeradbiomed.2021.04.031

DO - 10.1016/j.freeradbiomed.2021.04.031

M3 - Review article

C2 - 34052345

AN - SCOPUS:85108176359

SN - 0891-5849

VL - 172

SP - 58

EP - 64

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

ER -