Oxygen indirectly regulates nitric oxide availability

Philip E. James; J. Joan Parton; Simon K. Jackson; Michael P. Frenneaux

Oxygen indirectly regulates nitric oxide availability

Philip E. James^*
, J. Joan Parton
, Simon K. Jackson
, Michael P. Frenneaux

^*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod › adolygiad gan gymheiriaid

2 Dyfyniadau (Scopus)

Crynodeb

Oxygen is a critical substrate for both nitric oxide (NO) and superoxide (02-) biosynthesis. Previous studies have established that constitutive calcium-dependent NO synthase (NOS) and 02 producing NADPH-oxidase are affected at the level of gene expression and at a functional level. For example, hypoxia increases expression of the genes encoding both macrophage and endothelial NOS isoforms, and low oxygen tension attenuates NOS activity and NO-dependent vascular relaxation. Both NOS and NADPH-oxidase participate in modulation of vascular tone ° although how oxygen regulates endothelial response is unclear. We have previously demonstrated the dependence of macrophage NADPH-oxidase on the cellular distribution of oxygen, and both superoxide and NO production by endothelial cells.

Iaith wreiddiol	Saesneg
Teitl	Oxygen Transport To Tissue XXIII
Is-deitl	Oxygen Measurements in the 21st Century: Basic Techniques and Clinical Relevance
Tudalennau	139-143
Nifer y tudalennau	5
Statws	Cyhoeddwyd - 2003
Cyhoeddwyd yn allanol	Ie

Cyfres gyhoeddiadau

Enw	Advances in Experimental Medicine and Biology
Cyfrol	510
ISSN (Argraffiad)	0065-2598

Mynediad at Ddogfen

https://link.springer.com/chapter/10.1007/978-1-4615-0205-0_23

Ffeiliau eraill a chysylltiadau

Dolen i’r cyhoeddiad yn Scopus

Dyfynnu hyn

James, P. E., Parton, J. J., Jackson, S. K., & Frenneaux, M. P. (2003). Oxygen indirectly regulates nitric oxide availability. Yn Oxygen Transport To Tissue XXIII: Oxygen Measurements in the 21st Century: Basic Techniques and Clinical Relevance (tt. 139-143). (Advances in Experimental Medicine and Biology; Cyfrol 510). https://link.springer.com/chapter/10.1007/978-1-4615-0205-0_23

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title = "Oxygen indirectly regulates nitric oxide availability",

abstract = "Oxygen is a critical substrate for both nitric oxide (NO) and superoxide (02-) biosynthesis. Previous studies have established that constitutive calcium-dependent NO synthase (NOS) and 02 producing NADPH-oxidase are affected at the level of gene expression and at a functional level. For example, hypoxia increases expression of the genes encoding both macrophage and endothelial NOS isoforms, and low oxygen tension attenuates NOS activity and NO-dependent vascular relaxation. Both NOS and NADPH-oxidase participate in modulation of vascular tone ° although how oxygen regulates endothelial response is unclear. We have previously demonstrated the dependence of macrophage NADPH-oxidase on the cellular distribution of oxygen, and both superoxide and NO production by endothelial cells.",

author = "James, \{Philip E.\} and Parton, \{J. Joan\} and Jackson, \{Simon K.\} and Frenneaux, \{Michael P.\}",

year = "2003",

language = "English",

series = "Advances in Experimental Medicine and Biology",

pages = "139--143",

booktitle = "Oxygen Transport To Tissue XXIII",

}

Oxygen indirectly regulates nitric oxide availability. / James, Philip E.; Parton, J. Joan; Jackson, Simon K. et al.
Oxygen Transport To Tissue XXIII: Oxygen Measurements in the 21st Century: Basic Techniques and Clinical Relevance. 2003. t. 139-143 (Advances in Experimental Medicine and Biology; Cyfrol 510).

Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod › adolygiad gan gymheiriaid

TY - CHAP

T1 - Oxygen indirectly regulates nitric oxide availability

AU - James, Philip E.

AU - Parton, J. Joan

AU - Jackson, Simon K.

AU - Frenneaux, Michael P.

PY - 2003

Y1 - 2003

N2 - Oxygen is a critical substrate for both nitric oxide (NO) and superoxide (02-) biosynthesis. Previous studies have established that constitutive calcium-dependent NO synthase (NOS) and 02 producing NADPH-oxidase are affected at the level of gene expression and at a functional level. For example, hypoxia increases expression of the genes encoding both macrophage and endothelial NOS isoforms, and low oxygen tension attenuates NOS activity and NO-dependent vascular relaxation. Both NOS and NADPH-oxidase participate in modulation of vascular tone ° although how oxygen regulates endothelial response is unclear. We have previously demonstrated the dependence of macrophage NADPH-oxidase on the cellular distribution of oxygen, and both superoxide and NO production by endothelial cells.

AB - Oxygen is a critical substrate for both nitric oxide (NO) and superoxide (02-) biosynthesis. Previous studies have established that constitutive calcium-dependent NO synthase (NOS) and 02 producing NADPH-oxidase are affected at the level of gene expression and at a functional level. For example, hypoxia increases expression of the genes encoding both macrophage and endothelial NOS isoforms, and low oxygen tension attenuates NOS activity and NO-dependent vascular relaxation. Both NOS and NADPH-oxidase participate in modulation of vascular tone ° although how oxygen regulates endothelial response is unclear. We have previously demonstrated the dependence of macrophage NADPH-oxidase on the cellular distribution of oxygen, and both superoxide and NO production by endothelial cells.

UR - https://www.scopus.com/pages/publications/0037227932

M3 - Chapter

C2 - 12580418

AN - SCOPUS:0037227932

T3 - Advances in Experimental Medicine and Biology

SP - 139

EP - 143

BT - Oxygen Transport To Tissue XXIII

ER -