Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression

Claire M. Kelly; Sophie V. Precious; Caroline Scherf; Richard Penketh; Nazar N. Amso; Alysia Battersby; Nicholas D. Allen; Stephen B. Dunnett; Anne E. Rosser

doi:10.1038/nmeth.1308

Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression

Claire M. Kelly^*
, Sophie V. Precious
, Caroline Scherf
, Richard Penketh
, Nazar N. Amso
, Alysia Battersby
, Nicholas D. Allen
, Stephen B. Dunnett
, Anne E. Rosser

^*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

41 Dyfyniadau (Scopus)

Crynodeb

Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell-derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	271-273
Nifer y tudalennau	3
Cyfnodolyn	Nature Methods
Cyfrol	6
Rhif cyhoeddi	4
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1038/nmeth.1308
Statws	Cyhoeddwyd - 8 Maw 2009
Cyhoeddwyd yn allanol	Ie

NDC y CU

Mae’r allbwn hwn yn cyfrannu at y Nod(au) Datblygu Cynaliadwy canlynol

NDC 3 Iechyd a Llesiant Da

Mynediad at Ddogfen

10.1038/nmeth.1308

Ffeiliau eraill a chysylltiadau

Dolen i’r cyhoeddiad yn Scopus

Dyfynnu hyn

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abstract = "Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell-derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.",

author = "Kelly, \{Claire M.\} and Precious, \{Sophie V.\} and Caroline Scherf and Richard Penketh and Amso, \{Nazar N.\} and Alysia Battersby and Allen, \{Nicholas D.\} and Dunnett, \{Stephen B.\} and Rosser, \{Anne E.\}",

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AU - Amso, Nazar N.

AU - Battersby, Alysia

AU - Allen, Nicholas D.

AU - Dunnett, Stephen B.

AU - Rosser, Anne E.

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AB - Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell-derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.

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