Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression

Claire M. Kelly*, Sophie V. Precious, Caroline Scherf, Richard Penketh, Nazar N. Amso, Alysia Battersby, Nicholas D. Allen, Stephen B. Dunnett, Anne E. Rosser

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

40 Dyfyniadau (Scopus)

Crynodeb

Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell-derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.

Iaith wreiddiolSaesneg
Tudalennau (o-i)271-273
Nifer y tudalennau3
CyfnodolynNature Methods
Cyfrol6
Rhif cyhoeddi4
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 8 Maw 2009
Cyhoeddwyd yn allanolIe

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