Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype

Bryony A. Curry, Aimee L. Drane*, Rebeca Atencia, Yedra Feltrer, Thalita Calvi, Ellie L. Milnes, Sophie Moittié, Annika Weigold, Tobias Knauf-Witzens, Arga Sawung Kusuma, Glyn Howatson, Christopher Palmer, Mike R. Stembridge, John E. Gorzynski, Neil D. Eves, Tony G. Dawkins, Rob E. Shave*

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

Crynodeb

Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may reflect evolutionary divergence among closely-related species. Here, we compare the left ventricle (LV) across all extant members of the Hominidae taxon, using 2D echocardiography, to gain insight into the evolution of the human heart. We present compelling evidence that the human LV has diverged away from a more trabeculated phenotype present in all other great apes, towards a ventricular wall with proportionally greater compact myocardium, which was corroborated by post-mortem chimpanzee (Pan troglodytes) hearts. Speckle-tracking echocardiographic analyses identified a negative curvilinear relationship between the degree of trabeculation and LV systolic twist, revealing lower rotational mechanics in the trabeculated non-human great ape LV. This divergent evolution of the human heart may have facilitated the augmentation of cardiac output to support the metabolic and thermoregulatory demands of the human ecological niche.
Iaith wreiddiolSaesneg
Rhif yr erthygl682
Tudalennau (o-i)682
CyfnodolynCommunications Biology
Cyfrol7
Rhif cyhoeddi1
Dyddiad ar-lein cynnar14 Meh 2024
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 14 Meh 2024

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