Fractal analysis of viscoelastic data with automated gel point location and its potential application in the investigation of therapeutically modified blood coagulation

P. Adrian Evans, Matthew Lawrence, R. H.Keith Morris, Naresh Thirumalai, Roger Munro, Lisa Wakeman, Andrew Beddel, P. Rhodri Williams, Matthew Barrow, Daniel Curtis, M. Rowan Brown, Karl Hawkins*

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

6 Dyfyniadau (Scopus)

Crynodeb

This study reports an automated numerical method for the location of the gel point in oscillatory shear data and demonstrates its potential application in measurements on therapeutically modified (heparinised) samples of healthy coagulating blood. Heparin prolongs the onset of clot formation and has a significant effect on the microstructure of the clot which is eventually formed. The results demonstrate the potential of this rheometrical technique as a new tool for monitoring the effect of heparin on samples of whole blood with significantly better linearity of response within the therapeutic range than another global coagulation monitoring technique (thromboelastography) which has previously been used.

Iaith wreiddiolSaesneg
Tudalennau (o-i)901-908
Nifer y tudalennau8
CyfnodolynRheologica Acta
Cyfrol49
Rhif cyhoeddi9
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 25 Gorff 2010

Dyfynnu hyn