Feo - Transport of ferrous iron into bacteria

Michaël L. Cartron, Sarah Maddocks, Paul Gillingham, C. Jeremy Craven, Simon C. Andrews*

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

291 Dyfyniadau (Scopus)

Crynodeb

Bacteria commonly utilise a unique type of transporter, called Feo, to specifically acquire the ferrous (Fe2+) form of iron from their environment. Enterobacterial Feo systems are composed of three proteins: FeoA, a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. We provide a review of the current literature combined with a bioinformatic assessment of bacterial Feo systems showing how they exhibit common features, as well as differences in organisation and composition which probably reflect variations in mechanisms employed and function.

Iaith wreiddiolSaesneg
Tudalennau (o-i)143-157
Nifer y tudalennau15
CyfnodolynBioMetals
Cyfrol19
Rhif cyhoeddi2
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - Ebr 2006
Cyhoeddwyd yn allanolIe

Dyfynnu hyn