Exploring autonomic nervous system dysfunction in patients with cancer cachexia: A pilot study

Alpna Chauhan; Ashika Sequeria; Cathann Manderson; Matthew Maddocks; David Wasley; Andrew Wilcock

doi:10.1016/j.autneu.2011.09.006

Exploring autonomic nervous system dysfunction in patients with cancer cachexia: A pilot study

Alpna Chauhan
, Ashika Sequeria
, Cathann Manderson
, Matthew Maddocks
, David Wasley
, Andrew Wilcock^*

^*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

20 Dyfyniadau (Scopus)

Crynodeb

Introduction: Abnormalities of the autonomic nervous system (ANS) have been associated with cachexia. Methods: In nine cancer patients who had lost weight and nine age-matched healthy volunteers heart rate variability (HRV) components were determined, together with serum cortisol and urinary catecholamines/metanephrines. Results: Compared to volunteers, patients exhibited a global reduction in HRV parameters, significantly so for high frequency, low frequency and total power (median values ms ² 103 vs. 313, 62 vs. 148 and 316 vs. 736 respectively, P<0.05). Biochemical values did not differ. Conclusion: Our results suggest the presence of ANS dysfunction in patients with cancer cachexia, with reduction in both sympathetic and parasympathetic components.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	93-95
Nifer y tudalennau	3
Cyfnodolyn	Autonomic Neuroscience: Basic and Clinical
Cyfrol	166
Rhif cyhoeddi	1-2
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/j.autneu.2011.09.006
Statws	Cyhoeddwyd - 19 Hyd 2011

NDC y CU

Mae’r allbwn hwn yn cyfrannu at y Nod(au) Datblygu Cynaliadwy canlynol

NDC 3 Iechyd a Llesiant Da

Mynediad at Ddogfen

10.1016/j.autneu.2011.09.006

Ffeiliau eraill a chysylltiadau

Dolen i’r cyhoeddiad yn Scopus

Dyfynnu hyn

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abstract = "Introduction: Abnormalities of the autonomic nervous system (ANS) have been associated with cachexia. Methods: In nine cancer patients who had lost weight and nine age-matched healthy volunteers heart rate variability (HRV) components were determined, together with serum cortisol and urinary catecholamines/metanephrines. Results: Compared to volunteers, patients exhibited a global reduction in HRV parameters, significantly so for high frequency, low frequency and total power (median values ms 2 103 vs. 313, 62 vs. 148 and 316 vs. 736 respectively, P<0.05). Biochemical values did not differ. Conclusion: Our results suggest the presence of ANS dysfunction in patients with cancer cachexia, with reduction in both sympathetic and parasympathetic components.",

keywords = "Autonomic nervous system, Cancer cachexia, Heart rate variability",

author = "Alpna Chauhan and Ashika Sequeria and Cathann Manderson and Matthew Maddocks and David Wasley and Andrew Wilcock",

year = "2011",

month = oct,

day = "19",

doi = "10.1016/j.autneu.2011.09.006",

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T1 - Exploring autonomic nervous system dysfunction in patients with cancer cachexia

T2 - A pilot study

AU - Chauhan, Alpna

AU - Sequeria, Ashika

AU - Manderson, Cathann

AU - Maddocks, Matthew

AU - Wasley, David

AU - Wilcock, Andrew

PY - 2011/10/19

Y1 - 2011/10/19

N2 - Introduction: Abnormalities of the autonomic nervous system (ANS) have been associated with cachexia. Methods: In nine cancer patients who had lost weight and nine age-matched healthy volunteers heart rate variability (HRV) components were determined, together with serum cortisol and urinary catecholamines/metanephrines. Results: Compared to volunteers, patients exhibited a global reduction in HRV parameters, significantly so for high frequency, low frequency and total power (median values ms 2 103 vs. 313, 62 vs. 148 and 316 vs. 736 respectively, P<0.05). Biochemical values did not differ. Conclusion: Our results suggest the presence of ANS dysfunction in patients with cancer cachexia, with reduction in both sympathetic and parasympathetic components.

AB - Introduction: Abnormalities of the autonomic nervous system (ANS) have been associated with cachexia. Methods: In nine cancer patients who had lost weight and nine age-matched healthy volunteers heart rate variability (HRV) components were determined, together with serum cortisol and urinary catecholamines/metanephrines. Results: Compared to volunteers, patients exhibited a global reduction in HRV parameters, significantly so for high frequency, low frequency and total power (median values ms 2 103 vs. 313, 62 vs. 148 and 316 vs. 736 respectively, P<0.05). Biochemical values did not differ. Conclusion: Our results suggest the presence of ANS dysfunction in patients with cancer cachexia, with reduction in both sympathetic and parasympathetic components.

KW - Autonomic nervous system

KW - Cancer cachexia

KW - Heart rate variability

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