TY - JOUR
T1 - Defining an ageing-related pathology, disease or syndrome
T2 - International Consensus Statement
AU - ICCARP
AU - Short, Emma
AU - Zemel, Michael
AU - Yu, Emma
AU - Chung, Tham Yhi
AU - Yeo, Leonard L.L.
AU - Witkowski, Jacek M.
AU - Willis, Rosalind
AU - Whitney, Susan L.
AU - Weinberger, Birgit
AU - Weight, Caroline
AU - Webster, Anthony
AU - Watkins, Adam J.
AU - Wakefield, Richard
AU - Walker, James
AU - Vyazovskiy, Vladyslav
AU - Vukanovic, Vesna
AU - Vinciguerra, Manlio
AU - Verschoor, Chris
AU - Vernooij, Meike W.
AU - Venkat, Reddy
AU - Venables, Zoe C.
AU - Veighey, Kristin
AU - Vallabh, Neeru A.
AU - Whittaker, Anna
AU - Vinke, Elisabeth J.
AU - Tsimpida, Dialechti
AU - Tsochatzis, Emmanuel A.
AU - Trivedi, Drupad
AU - Tree, Jeremy
AU - Timmons, James
AU - Tiganescu, Ana
AU - Mohd, Tengku Amatullah Madeehah Tengku
AU - Tavares, Adriana A.S.
AU - Tatler, Amanda
AU - Tanzi, Rudolph E.
AU - Tan, Ai Lyn
AU - Tadanki, Vyshnavi
AU - Svensson, Jonas
AU - Sussman, Mark
AU - Subbarayan, Selvarani
AU - Stone, Keeron
AU - Stewart, Claire
AU - Steel, Karen P.
AU - Steel, David
AU - Raghavan, Ramasamy Srinivasa
AU - Spyridopoulos, Ioakim
AU - Snelling, Sarah
AU - Smith, Rebecca
AU - Erusalimsky, Jorge D.
AU - Bentley, Barry
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/9/21
Y1 - 2024/9/21
N2 - Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndromes. This will allow societies to better identify, quantify, understand and meet the healthcare, workforce, well-being and socioeconomic needs of ageing populations, whilst supporting the development and utilisation of interventions to prevent or to slow, halt or reverse the progression of ageing-related pathologies. The foundation for developing such classification and staging systems is to define the scope of what constitutes an ageing-related pathology, disease or syndrome. To this end, a consensus meeting was hosted by the International Consortium to Classify Ageing-Related Pathologies (ICCARP), on February 19, 2024, in Cardiff, UK, and was attended by 150 recognised experts. Discussions and voting were centred on provisional criteria that had been distributed prior to the meeting. The participants debated and voted on these. Each criterion required a consensus agreement of ≥ 70% for approval. The accepted criteria for an ageing-related pathology, disease or syndrome were (1) develops and/or progresses with increasing chronological age; (2) should be associated with, or contribute to, functional decline or an increased susceptibility to functional decline and (3) evidenced by studies in humans. Criteria for an ageing-related pathology, disease or syndrome have been agreed by an international consortium of subject experts. These criteria will now be used by the ICCARP for the classification and ultimately staging of ageing-related pathologies, diseases and syndromes.
AB - Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndromes. This will allow societies to better identify, quantify, understand and meet the healthcare, workforce, well-being and socioeconomic needs of ageing populations, whilst supporting the development and utilisation of interventions to prevent or to slow, halt or reverse the progression of ageing-related pathologies. The foundation for developing such classification and staging systems is to define the scope of what constitutes an ageing-related pathology, disease or syndrome. To this end, a consensus meeting was hosted by the International Consortium to Classify Ageing-Related Pathologies (ICCARP), on February 19, 2024, in Cardiff, UK, and was attended by 150 recognised experts. Discussions and voting were centred on provisional criteria that had been distributed prior to the meeting. The participants debated and voted on these. Each criterion required a consensus agreement of ≥ 70% for approval. The accepted criteria for an ageing-related pathology, disease or syndrome were (1) develops and/or progresses with increasing chronological age; (2) should be associated with, or contribute to, functional decline or an increased susceptibility to functional decline and (3) evidenced by studies in humans. Criteria for an ageing-related pathology, disease or syndrome have been agreed by an international consortium of subject experts. These criteria will now be used by the ICCARP for the classification and ultimately staging of ageing-related pathologies, diseases and syndromes.
KW - Ageing
KW - Ageing-related pathology
KW - Disease
KW - Longevity
KW - Syndrome
UR - http://www.scopus.com/inward/record.url?scp=85204463482&partnerID=8YFLogxK
U2 - 10.1007/s11357-024-01315-9
DO - 10.1007/s11357-024-01315-9
M3 - Article
AN - SCOPUS:85204463482
SN - 2509-2715
JO - GeroScience
JF - GeroScience
ER -