TY - JOUR
T1 - Characterizing Age Effects on Wideband Absorbance in Normal-Hearing Children Via-Statistical and Machine Learning Analyses
AU - Qiu, Jie
AU - Shen, Chanfeng
AU - Wang, Yan
AU - Lai, Xiaohui
AU - Mu, Yi
AU - Zhao, Fei
AU - Liu, Wen
AU - Jiang, Wen
N1 - © 2026 PLA General Hospital Department of Otolaryngology Head and Neck Surgery. Publishing services by Tsinghua University Press.
PY - 2026/7/27
Y1 - 2026/7/27
N2 - Objective: To characterize age-related changes in wideband absorbance (WBA) among normal-hearing children aged 0–6 years through combined statistical and machine learning analyses, and to establish developmental reference patterns supporting pediatric middle-ear diagnostics.Methods:A cross-sectional study was conducted on 579 children (1158 ears) categorized into five age groups. All participants passed age-appropriate hearing screenings. WBA was measured under both ambient pressure (AP) and tympanometric peak pressure (TPP) conditions across 16 frequencies (226–8000 Hz). Repeated-measures analysis of variance examined the effects of age, ear side, and gender, while Random Forest classifiers and principal component analysis (PCA) explored the discriminative structure and feature importance of WBA data.Results:Neither gender nor ear side had a significantly effect on WBA patterns (p > 0.05). In constrast, Age significantly influenced WBA patterns (p < 0.001). Younger infants (< 6 months) exhibited dual-peaked “M-shaped” curves, whereas older children (3–6 years) showed single-peaked, inverted “U-shaped” profiles centered near 1600 Hz, reflecting progressive middle-ear maturation. The Random Forest model achieved a mean accuracy of 0.73 (balanced accuracy = 0.58), with the top-ranked predictors (AP_1000, and AP_793) emphasizing low-to-mid frequency absorbance and pressure-compensation effects as key age indicators. PCA with k-means clustering further revealed partially distinct groupings aligned with chronological age, supporting the developmental encoding of WBA responses.Conclusion:WBA demonstrates distinct, age-dependent acoustic characteristics that correspond to physiological maturation of the middle ear. These findings provide a quantitative reference for pediatric wideband acoustic immittance and highlight the potential of machine learning in delineating developmental auditory patterns.
AB - Objective: To characterize age-related changes in wideband absorbance (WBA) among normal-hearing children aged 0–6 years through combined statistical and machine learning analyses, and to establish developmental reference patterns supporting pediatric middle-ear diagnostics.Methods:A cross-sectional study was conducted on 579 children (1158 ears) categorized into five age groups. All participants passed age-appropriate hearing screenings. WBA was measured under both ambient pressure (AP) and tympanometric peak pressure (TPP) conditions across 16 frequencies (226–8000 Hz). Repeated-measures analysis of variance examined the effects of age, ear side, and gender, while Random Forest classifiers and principal component analysis (PCA) explored the discriminative structure and feature importance of WBA data.Results:Neither gender nor ear side had a significantly effect on WBA patterns (p > 0.05). In constrast, Age significantly influenced WBA patterns (p < 0.001). Younger infants (< 6 months) exhibited dual-peaked “M-shaped” curves, whereas older children (3–6 years) showed single-peaked, inverted “U-shaped” profiles centered near 1600 Hz, reflecting progressive middle-ear maturation. The Random Forest model achieved a mean accuracy of 0.73 (balanced accuracy = 0.58), with the top-ranked predictors (AP_1000, and AP_793) emphasizing low-to-mid frequency absorbance and pressure-compensation effects as key age indicators. PCA with k-means clustering further revealed partially distinct groupings aligned with chronological age, supporting the developmental encoding of WBA responses.Conclusion:WBA demonstrates distinct, age-dependent acoustic characteristics that correspond to physiological maturation of the middle ear. These findings provide a quantitative reference for pediatric wideband acoustic immittance and highlight the potential of machine learning in delineating developmental auditory patterns.
KW - Children
KW - Machine learning
KW - Middle-ear maturation
KW - Normative data
KW - Wideband absorbance
UR - https://www.scopus.com/pages/publications/105046566434
U2 - 10.26599/JOTO.2026.9540071
DO - 10.26599/JOTO.2026.9540071
M3 - Article
C2 - 42620885
AN - SCOPUS:105046566434
SN - 1672-2930
VL - 21
SP - 183
EP - 190
JO - Journal of Otology
JF - Journal of Otology
IS - 3
ER -