TY - JOUR
T1 - Centenarians—the way to healthy vascular ageing and longevity
T2 - a review from VascAgeNet
AU - Summer, Sabrina
AU - Borrell-Pages, Maria
AU - Bruno, Rosa Maria
AU - Climie, Rachel E.
AU - Dipla, Konstantina
AU - Dogan, Aysenur
AU - Eruslanova, Kseniia
AU - Fraenkel, Emil
AU - Mattace-Raso, Francesco
AU - Pugh, Christopher J.A.
AU - Rochfort, Keith D.
AU - Ross, Mark
AU - Roth, Lynn
AU - Schmidt-Trucksäss, Arno
AU - Schwarz, Dennis
AU - Shadiow, James
AU - Sohrabi, Yahya
AU - Sonnenberg, Jannik
AU - Tura-Ceide, Olga
AU - Guvenc Tuna, Bilge
AU - Julve, Josep
AU - Dogan, Soner
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12/27
Y1 - 2024/12/27
N2 - The prevalence of centenarians, people who lived 100 years and longer, is steadily growing in the last decades. This exceptional longevity is based on multifaceted processes influenced by a combination of intrinsic and extrinsic factors such as sex, (epi-)genetic factors, gut microbiota, cellular metabolism, exposure to oxidative stress, immune status, cardiovascular risk factors, environmental factors, and lifestyle behavior. Epidemiologically, the incidence rate of cardiovascular diseases is reduced in healthy centenarians along with late onset of age-related diseases compared with the general aged population. Understanding the mechanisms that affect vascular ageing in centenarians and the underlying factors could offer valuable insights for developing strategies to improve overall healthy life span in the elderly. This review discusses these key factors influencing vascular ageing and how their modulation could foster healthy longevity.
AB - The prevalence of centenarians, people who lived 100 years and longer, is steadily growing in the last decades. This exceptional longevity is based on multifaceted processes influenced by a combination of intrinsic and extrinsic factors such as sex, (epi-)genetic factors, gut microbiota, cellular metabolism, exposure to oxidative stress, immune status, cardiovascular risk factors, environmental factors, and lifestyle behavior. Epidemiologically, the incidence rate of cardiovascular diseases is reduced in healthy centenarians along with late onset of age-related diseases compared with the general aged population. Understanding the mechanisms that affect vascular ageing in centenarians and the underlying factors could offer valuable insights for developing strategies to improve overall healthy life span in the elderly. This review discusses these key factors influencing vascular ageing and how their modulation could foster healthy longevity.
KW - Cardiovascular diseases
KW - Centenarians
KW - Health span
KW - Healthy vascular ageing
UR - https://www.scopus.com/pages/publications/85213031227
U2 - 10.1007/s11357-024-01467-8
DO - 10.1007/s11357-024-01467-8
M3 - Review article
AN - SCOPUS:85213031227
SN - 2509-2715
VL - 47
SP - 685
EP - 702
JO - GeroScience
JF - GeroScience
IS - 1
ER -
NDC 3 Iechyd a Llesiant Da