Antimicrobial Efficacy and Stability of an N-Chlorotaurine Gel for Chronic Wound Treatment

The stability of a formulation of 1% N-chlorotaurine (NCT) in a smectite clay as a gel was characterized using a range of physicochemical parameters, and its antimicrobial efficacy was determined against Staphylococcus aureus and Pseudomonas aeruginosa. The stability of the NCT gel was determined by UV–visible spectroscopy. The efficacy against S. aureus and P. aeruginosa was tested in single- and dual-species biofilms using a dynamic in vitro chronic wound infection model and only showed efficacy against S. aureus. The gel proved stable over time at room temperature and at 4 °C with half-life values of ~161 days and 4 years, respectively. The compatibility of NCT with the preferred pH of the clay gel makes this formulation a candidate for durable topical application to chronic wounds.