A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase

Friederike I. Nollmann; Antje K. Heinrich; Alexander O. Brachmann; Christophe Morisseau; Krishnendu Mukherjee; Ángel M. Casanova-Torres; Frederic Strobl; David Kleinhans; Sebastian Kinski; Katharina Schultz; Michael L. Beeton; Marcel Kaiser; Ya Yun Chu; Long Phan Ke; Aunchalee Thanwisai; Kenan A.J. Bozhüyük; Narisara Chantratita; Friedrich Götz; Nick R. Waterfield; Andreas Vilcinskas; Ernst H.K. Stelzer; Heidi Goodrich-Blair; Bruce D. Hammock; Helge B. Bode

doi:10.1002/cbic.201402650

A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase

Friederike I. Nollmann
, Antje K. Heinrich
, Alexander O. Brachmann
, Christophe Morisseau
, Krishnendu Mukherjee
, Ángel M. Casanova-Torres
, Frederic Strobl
, David Kleinhans
, Sebastian Kinski
, Katharina Schultz
, Michael L. Beeton
, Marcel Kaiser
, Ya Yun Chu
, Long Phan Ke
, Aunchalee Thanwisai
, Kenan A.J. Bozhüyük
, Narisara Chantratita
, Friedrich Götz
, Nick R. Waterfield
, Andreas Vilcinskas

Ernst H.K. Stelzer, Heidi Goodrich-Blair, Bruce D. Hammock, Helge B. Bode^*

^*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

40 Dyfyniadau (Scopus)

Crynodeb

Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	766-771
Nifer y tudalennau	6
Cyfnodolyn	ChemBioChem
Cyfrol	16
Rhif cyhoeddi	5
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1002/cbic.201402650
Statws	Cyhoeddwyd - 25 Chwef 2015

Mynediad at Ddogfen

10.1002/cbic.201402650Trwydded: CC BY

Ffeiliau eraill a chysylltiadau

Dolen i’r cyhoeddiad yn Scopus

Dyfynnu hyn

Nollmann, F. I., Heinrich, A. K., Brachmann, A. O., Morisseau, C., Mukherjee, K., Casanova-Torres, Á. M., Strobl, F., Kleinhans, D., Kinski, S., Schultz, K., Beeton, M. L., Kaiser, M., Chu, Y. Y., Phan Ke, L., Thanwisai, A., Bozhüyük, K. A. J., Chantratita, N., Götz, F., Waterfield, N. R., ... Bode, H. B. (2015). A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. ChemBioChem, 16(5), 766-771. https://doi.org/10.1002/cbic.201402650

@article{babd40a69ced4c458e7a7cbdc50a28ac,

title = "A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase",

abstract = "Simple urea compounds ({"}phurealipids{"}) have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.",

keywords = "Photorhabdus, biosynthesis, entomopathogenic bacteria, juvenile hormone epoxide hydrolase inhibitor, natural products",

author = "Nollmann, \{Friederike I.\} and Heinrich, \{Antje K.\} and Brachmann, \{Alexander O.\} and Christophe Morisseau and Krishnendu Mukherjee and Casanova-Torres, \{{\'A}ngel M.\} and Frederic Strobl and David Kleinhans and Sebastian Kinski and Katharina Schultz and Beeton, \{Michael L.\} and Marcel Kaiser and Chu, \{Ya Yun\} and \{Phan Ke\}, Long and Aunchalee Thanwisai and Bozh{\"u}y{\"u}k, \{Kenan A.J.\} and Narisara Chantratita and Friedrich G{\"o}tz and Waterfield, \{Nick R.\} and Andreas Vilcinskas and Stelzer, \{Ernst H.K.\} and Heidi Goodrich-Blair and Hammock, \{Bruce D.\} and Bode, \{Helge B.\}",

note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2015",

month = feb,

day = "25",

doi = "10.1002/cbic.201402650",

language = "English",

volume = "16",

pages = "766--771",

journal = "ChemBioChem",

issn = "1439-4227",

number = "5",

}

Nollmann, FI, Heinrich, AK, Brachmann, AO, Morisseau, C, Mukherjee, K, Casanova-Torres, ÁM, Strobl, F, Kleinhans, D, Kinski, S, Schultz, K, Beeton, ML, Kaiser, M, Chu, YY, Phan Ke, L, Thanwisai, A, Bozhüyük, KAJ, Chantratita, N, Götz, F, Waterfield, NR, Vilcinskas, A, Stelzer, EHK, Goodrich-Blair, H, Hammock, BD & Bode, HB 2015, 'A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase', ChemBioChem, cyfrol. 16, rhif 5, tt. 766-771. https://doi.org/10.1002/cbic.201402650

TY - JOUR

T1 - A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase

AU - Nollmann, Friederike I.

AU - Heinrich, Antje K.

AU - Brachmann, Alexander O.

AU - Morisseau, Christophe

AU - Mukherjee, Krishnendu

AU - Casanova-Torres, Ángel M.

AU - Strobl, Frederic

AU - Kleinhans, David

AU - Kinski, Sebastian

AU - Schultz, Katharina

AU - Beeton, Michael L.

AU - Kaiser, Marcel

AU - Chu, Ya Yun

AU - Phan Ke, Long

AU - Thanwisai, Aunchalee

AU - Bozhüyük, Kenan A.J.

AU - Chantratita, Narisara

AU - Götz, Friedrich

AU - Waterfield, Nick R.

AU - Vilcinskas, Andreas

AU - Stelzer, Ernst H.K.

AU - Goodrich-Blair, Heidi

AU - Hammock, Bruce D.

AU - Bode, Helge B.

PY - 2015/2/25

Y1 - 2015/2/25

N2 - Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.

AB - Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.

KW - Photorhabdus

KW - biosynthesis

KW - entomopathogenic bacteria

KW - juvenile hormone epoxide hydrolase inhibitor

KW - natural products

UR - https://www.scopus.com/pages/publications/84924856546

U2 - 10.1002/cbic.201402650

DO - 10.1002/cbic.201402650

M3 - Article

C2 - 25711603

AN - SCOPUS:84924856546

SN - 1439-4227

VL - 16

SP - 766

EP - 771

JO - ChemBioChem

JF - ChemBioChem

IS - 5

ER -