A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

Matthew J. Lawrence; Ahmed Sabra; Gavin Mills; Suresh G. Pillai; Wendy Abdullah; Karl Hawkins; Roger H.K. Morris; Simon J. Davidson; Lindsay A. D'Silva; Daniel J. Curtis; Martin R. Brown; John W. Weisel; Phylip R. Williams; Phillip A. Evans

doi:10.1111/bjh.13173

A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

Matthew J. Lawrence
, Ahmed Sabra
, Gavin Mills
, Suresh G. Pillai
, Wendy Abdullah
, Karl Hawkins
, Roger H.K. Morris
, Simon J. Davidson
, Lindsay A. D'Silva
, Daniel J. Curtis
, Martin R. Brown
, John W. Weisel
, Phylip R. Williams
, Phillip A. Evans^*

^*Awdur cyfatebol y gwaith hwn

Ysgol Chwaraeon a Gwyddorau Iechyd Caerdydd

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

31 Dyfyniadau (Scopus)

4 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

Summary: This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (d_f) and clot formation time (T_GP). d_f was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The 'abnormal' clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of d_f in first time VTE patients who later develop a secondary event indicates that d_f may identify those at risk of recurrence.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	571-575
Nifer y tudalennau	5
Cyfnodolyn	British Journal of Haematology
Cyfrol	168
Rhif cyhoeddi	4
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1111/bjh.13173
Statws	Cyhoeddwyd - 10 Hyd 2014

Mynediad at Ddogfen

10.1111/bjh.13173

A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism-Lawrence MLlawysgrif awdur wedi’i dderbyn, 425 KBTrwydded: Under Copyright

Ffeiliau eraill a chysylltiadau

Dolen i’r cyhoeddiad yn Scopus

Dyfynnu hyn

Lawrence, M. J., Sabra, A., Mills, G., Pillai, S. G., Abdullah, W., Hawkins, K., Morris, R. H. K., Davidson, S. J., D'Silva, L. A., Curtis, D. J., Brown, M. R., Weisel, J. W., Williams, P. R., & Evans, P. A. (2014). A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism. British Journal of Haematology, 168(4), 571-575. https://doi.org/10.1111/bjh.13173

@article{0e28847c24754986b1fb6fcbdc3fa2f3,

title = "A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism",

abstract = "Summary: This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The 'abnormal' clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence.",

keywords = "Anticoagulation, Blood coagulation, Haemostasis, Venous thrombosis, Warfarin",

author = "Lawrence, \{Matthew J.\} and Ahmed Sabra and Gavin Mills and Pillai, \{Suresh G.\} and Wendy Abdullah and Karl Hawkins and Morris, \{Roger H.K.\} and Davidson, \{Simon J.\} and D'Silva, \{Lindsay A.\} and Curtis, \{Daniel J.\} and Brown, \{Martin R.\} and Weisel, \{John W.\} and Williams, \{Phylip R.\} and Evans, \{Phillip A.\}",

note = "Publisher Copyright: {\textcopyright} 2014 John Wiley \& Sons Ltd.",

year = "2014",

month = oct,

day = "10",

doi = "10.1111/bjh.13173",

language = "English",

volume = "168",

pages = "571--575",

journal = "British Journal of Haematology",

issn = "0007-1048",

number = "4",

}

Lawrence, MJ, Sabra, A, Mills, G, Pillai, SG, Abdullah, W, Hawkins, K, Morris, RHK, Davidson, SJ, D'Silva, LA, Curtis, DJ, Brown, MR, Weisel, JW, Williams, PR & Evans, PA 2014, 'A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism', British Journal of Haematology, cyfrol. 168, rhif 4, tt. 571-575. https://doi.org/10.1111/bjh.13173

TY - JOUR

T1 - A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

AU - Lawrence, Matthew J.

AU - Sabra, Ahmed

AU - Mills, Gavin

AU - Pillai, Suresh G.

AU - Abdullah, Wendy

AU - Hawkins, Karl

AU - Morris, Roger H.K.

AU - Davidson, Simon J.

AU - D'Silva, Lindsay A.

AU - Curtis, Daniel J.

AU - Brown, Martin R.

AU - Weisel, John W.

AU - Williams, Phylip R.

AU - Evans, Phillip A.

PY - 2014/10/10

Y1 - 2014/10/10

N2 - Summary: This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The 'abnormal' clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence.

AB - Summary: This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The 'abnormal' clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence.

KW - Anticoagulation

KW - Blood coagulation

KW - Haemostasis

KW - Venous thrombosis

KW - Warfarin

UR - https://www.scopus.com/pages/publications/84923094213

U2 - 10.1111/bjh.13173

DO - 10.1111/bjh.13173

M3 - Article

C2 - 25302653

AN - SCOPUS:84923094213

SN - 0007-1048

VL - 168

SP - 571

EP - 575

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -