A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan

sally chappell; Neil  Evans; Rachel Errington; Imtiaz A. Khan; Lee Campbell; Reza Ali; Keith Godfrey; Paul Smith

doi:10.1016/j.cmpb.2007.11.002

A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan

sally chappell, Neil Evans, Rachel Errington, Imtiaz A. Khan, Lee Campbell, Reza Ali, Keith Godfrey, Paul Smith

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

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A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.

Iaith wreiddiol	Saesneg
Cyfnodolyn	Computer Methods and Programs in Biomedicine
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/j.cmpb.2007.11.002
Statws	Cyhoeddwyd - 20 Rhag 2007
Cyhoeddwyd yn allanol	Ie

NDC y CU

Mae’r allbwn hwn yn cyfrannu at y Nod(au) Datblygu Cynaliadwy canlynol

Mynediad at Ddogfen

10.1016/j.cmpb.2007.11.002

Dyfynnu hyn

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title = "A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan",

abstract = "A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.",

author = "sally chappell and Neil Evans and Rachel Errington and Khan, {Imtiaz A.} and Lee Campbell and Reza Ali and Keith Godfrey and Paul Smith",

year = "2007",

month = dec,

day = "20",

doi = "10.1016/j.cmpb.2007.11.002",

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T1 - A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan

AU - chappell, sally

AU - Evans, Neil

AU - Errington, Rachel

AU - Khan, Imtiaz A.

AU - Campbell, Lee

AU - Ali, Reza

AU - Godfrey, Keith

AU - Smith, Paul

PY - 2007/12/20

Y1 - 2007/12/20

N2 - A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.

AB - A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.

U2 - 10.1016/j.cmpb.2007.11.002

DO - 10.1016/j.cmpb.2007.11.002

M3 - Article

SN - 1985-2023

JO - Computer Methods and Programs in Biomedicine

JF - Computer Methods and Programs in Biomedicine

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